1-(3,4-二氟-2-羟基苯基)乙酮合成路线 (共 3 条)
反应条件
AlCl3, aluminium chloride in 1,2-dichloro-ethane
T=0°C; Reflux;
参考文献
ABBVIE INC.; Woller, Kevin R.; Gfesser, Gregory A.; Liu, Huaqing; Daanen, Jerome F.; Voight, Eric A.; Drizin, Irene I.; Shrestha, Anurupa; Mortell, Kathleen H.; Kym, Philip R.; Kort, Michael E.; Gomtsyan, Arthur
Patent: US2013/158067 A1, 2013 ;
Location in patent: Paragraph 0347 ;
反应条件
1: pyridine / dichloromethane / 16 h / 0 - 20 °C
2: AlCl3, aluminium chloride / 16 h / |Reflux
View Scheme
参考文献
ABBVIE INC.; Woller, Kevin R.; Gfesser, Gregory A.; Liu, Huaqing; Daanen, Jerome F.; Voight, Eric A.; Drizin, Irene I.; Shrestha, Anurupa; Mortell, Kathleen H.; Kym, Philip R.; Kort, Michael E.; Gomtsyan, Arthur
Patent: US2013/158067 A1, 2013 ;
反应条件
pyridine; 4-(N,N-dimethlyamino)pyridine in water; toluene
参考文献
Sugiura, Teruyo; Ushioda, Makoto
Patent: US2005/247910 A1, 2005 ;