1,2-二苄基 3-叔丁基哌嗪-1,2,3-三羧酸合成路线 （共 8 条）
反应条件
2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium hypochlorite; sodium chlorite in phosphate buffer; acetonitrile
pH=6.8;
参考文献
Henmi, Yoshiaki; Makino, Kazuishi; Yoshitomi, Yayoi; Hara, Osamu; Hamada, Yasumasa
Tetrahedron Asymmetry, 2004 , vol. 15, # 21 p. 3477 - 3481
反应条件
1.1: (R)-proline / acetonitrile / 15 h / 0 °C
1.2: 100 percent / NaBH4 / acetonitrile; ethanol / 0.67 h / 0 °C
2.1: 82 percent / imidazole / dimethylformamide / 3.5 h / 23 °C
3.1: 90 percent / NaH / dimethylformamide / 0.67 h / 0 °C
4.1: 97 percent / TBAF / tetrahydrofuran / 0.67 h / 0 °C
5.1: 91 percent / TEMPO; NaClO2; aq. NaClO / aq. phosphate buffer; acetonitrile / 4 h / 23 °C / pH 6.8
View Scheme
参考文献
Henmi, Yoshiaki; Makino, Kazuishi; Yoshitomi, Yayoi; Hara, Osamu; Hamada, Yasumasa
Tetrahedron Asymmetry, 2004 , vol. 15, # 21 p. 3477 - 3481
反应条件
1: 97 percent / TBAF / tetrahydrofuran / 0.67 h / 0 °C
2: 91 percent / TEMPO; NaClO2; aq. NaClO / aq. phosphate buffer; acetonitrile / 4 h / 23 °C / pH 6.8
View Scheme
参考文献
Henmi, Yoshiaki; Makino, Kazuishi; Yoshitomi, Yayoi; Hara, Osamu; Hamada, Yasumasa
Tetrahedron Asymmetry, 2004 , vol. 15, # 21 p. 3477 - 3481
反应条件
1.1: (R)-proline / acetonitrile / 15 h / 0 °C
1.2: 100 percent / NaBH4 / acetonitrile; ethanol / 0.67 h / 0 °C
2.1: 82 percent / imidazole / dimethylformamide / 3.5 h / 23 °C
3.1: 90 percent / NaH / dimethylformamide / 0.67 h / 0 °C
4.1: 97 percent / TBAF / tetrahydrofuran / 0.67 h / 0 °C
5.1: 91 percent / TEMPO; NaClO2; aq. NaClO / aq. phosphate buffer; acetonitrile / 4 h / 23 °C / pH 6.8
View Scheme
参考文献
Henmi, Yoshiaki; Makino, Kazuishi; Yoshitomi, Yayoi; Hara, Osamu; Hamada, Yasumasa
Tetrahedron Asymmetry, 2004 , vol. 15, # 21 p. 3477 - 3481
反应条件
1: 82 percent / imidazole / dimethylformamide / 3.5 h / 23 °C
2: 90 percent / NaH / dimethylformamide / 0.67 h / 0 °C
3: 97 percent / TBAF / tetrahydrofuran / 0.67 h / 0 °C
4: 91 percent / TEMPO; NaClO2; aq. NaClO / aq. phosphate buffer; acetonitrile / 4 h / 23 °C / pH 6.8
View Scheme
参考文献
Henmi, Yoshiaki; Makino, Kazuishi; Yoshitomi, Yayoi; Hara, Osamu; Hamada, Yasumasa
Tetrahedron Asymmetry, 2004 , vol. 15, # 21 p. 3477 - 3481
反应条件
1: 90 percent / NaH / dimethylformamide / 0.67 h / 0 °C
2: 97 percent / TBAF / tetrahydrofuran / 0.67 h / 0 °C
3: 91 percent / TEMPO; NaClO2; aq. NaClO / aq. phosphate buffer; acetonitrile / 4 h / 23 °C / pH 6.8
View Scheme
参考文献
Henmi, Yoshiaki; Makino, Kazuishi; Yoshitomi, Yayoi; Hara, Osamu; Hamada, Yasumasa
Tetrahedron Asymmetry, 2004 , vol. 15, # 21 p. 3477 - 3481
反应条件
1: R-(+)-proline / acetonitrile / 12 h / 0 °C
2: sodium chlorite; aminosulfonic acid / dichloromethane; water / 0 °C / |Large scale
3: sodium hydride / N,N-dimethyl-formamide / 12 h / 0 - 25 °C
View Scheme
参考文献
Chen, Yu; Lu, Yuwei; Zou, Qing; Chen, Huansheng; Ma, Dawei
Organic Process Research and Development, 2013 , vol. 17, # 9 p. 1209 - 1213
反应条件
1: R-(+)-proline / acetonitrile / 12 h / 0 °C
2: sodium chlorite; aminosulfonic acid / dichloromethane; water / 0 °C / |Large scale
3: sodium hydride / N,N-dimethyl-formamide / 12 h / 0 - 25 °C
View Scheme
参考文献
Chen, Yu; Lu, Yuwei; Zou, Qing; Chen, Huansheng; Ma, Dawei
Organic Process Research and Development, 2013 , vol. 17, # 9 p. 1209 - 1213
