顺式-4-苯基硫代-L-脯氨酸 (佐芬普利中间体)合成路线 （共 2 条）
反应条件
sodium carbonate in water 1 h;
参考文献
Krapcho; Turk; Cushman; Powell; DeForrest; Spitzmiller; Karanewsky; Duggan; Rovnvak; Schwartz; Natarajan; Godfrey; Ryono; Neubeck; Atwa; Petrillo Jr.
Journal of Medicinal Chemistry, 1988 , vol. 31, # 6 p. 1148 - 1160
反应条件
1: 97 percent / trimethylsilyl chloride / 10 h / Heating 2: 83 percent / 1-hydroxybenzotriazole; N,N-diisopropylethylamine; EDAC*HCl / tetrahydrofuran / 5 h 3: 3.0 g / N,N-diisopropylethylamine / 0.08 h / 60 °C 4: 20 mg / NaOH / methanol; H2O / 0.17 h / 50 °C View Scheme
参考文献
Matarrese, Mario; Salimbeni, Aldo; Turolla, Elia Anna; Turozzi, Damiano; Moresco, Rosa Maria; Poma, Davide; Magni, Fulvio; Todde, Sergio; Rossetti, Claudio; Sciarrone, Maria Teresa; Bianchi, Giuseppe; Kienle, Marzia Galli; Fazio, Ferruccio
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 3 p. 603 - 611
