1: 63 percent / KHMDS / tetrahydrofuran / 1.5 h / -78 °C 2: 96 percent / triethylsilane; LiCl / (PPh3)4Pd / dimethylformamide / 2 h / 55 °C 3: LiOH / tetrahydrofuran / 10 h / 0 - 20 °C 4: 0.0168 g / TFA / CH2Cl2 / 10 h View Scheme

1: t-AmONa / benzene / 0.5 h / Ambient temperature 2: Et3N / tetrahydrofuran; H2O / 1 h / Ambient temperature 3: 3 percent / O3 / CH2Cl2 / -78 °C 4: 60 percent / n-BuLi / tetrahydrofuran / -78 deg C, 2 min -> 0 deg C, 1 h 5: Jones reagent 6: KOH / 24 h / Ambient temperature View Scheme