4-氨基-1-((2R,3R,4R,5R)-3-氟-4-羟基-5-(羟基甲基)-3-甲基四氢呋喃-2-基)嘧啶-2(1H)-酮合成路线 (共 2 条)
反应条件
1: With sodium methylate in methanol T=60°C; 4 h; 2: With 2-methyl propanoic acid in methanol
参考文献
Carr, Robert; Hildbrand, Stefan; Hodges, Mark L.; Kammerer, Michael; Lang, John F.; Lawrimore, III, William J.; Nguyen, Dieu
Patent: US2013/324709 A1, 2013 ;
Location in patent: Paragraph 0053; 0054 ;
反应条件
pyridine
T=0°C; 1.66667 h; Inert atmosphere;
参考文献
PHARMASSET, INC.
Patent: US2010/16251 A1, 2010 ;
Location in patent: Page/Page column 35 ;