7-硝基-2H-1,4-苯并噁嗪-3-酮合成路线 （共 16 条）
反应条件
1: 2-amino-5-nitro-phenol With sodium hydrogencarbonate in water T=0°C; 0.5 h; 2: chloroacetyl chloride in water Reflux;
参考文献
Lee, Jeewoo; Tran, Phuong-Thao; Hoang, Van-Hai; Thorat, Shivaji A.; Kim, Sung Eun; Ann, Jihyae; Chang, Yu Jin; Nam, Dong Woo; Song, Hyundong; Mook-Jung, Inhee; Lee, Jiyoun
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 13 p. 3821 - 3830
反应条件
potassium fluoride in N,N-dimethyl-formamide T=50 - 60°C; 6 h;
参考文献
Shridhar; Gandhi Rao
Synthesis, 1982 , vol. No. 11, p. 986 - 987
反应条件
potassium carbonate in DMF (N,N-dimethyl-formamide) T=90°C; 24 h;
参考文献
PHARMACIA and UPJOHN COMPANY LLC
Patent: WO2005/82897 A1, 2005 ;
Location in patent: Page/Page column 29 ;
反应条件
potassium hydroxide in dimethyl sulfoxide
参考文献
Clairol Incorporated
Patent: US5055110 A1, 1991 ;
反应条件
1: acetone / 25 °C 2: NaOH-solution View Scheme
参考文献
Journal of the Chemical Society, , p. 3048
反应条件
nitric acid; acetic acid; sodium nitrite T=20°C; 4 h;
参考文献
Hanson, James R.; Richards, Lisa; Rozas, Panteleimon
Journal of Chemical Research, Miniprint, 2003 , # 11 p. 1120 - 1128
反应条件
ueber mehrere Stufen;
参考文献
US2724722 , ;
DE924694 , ;
反应条件
potassium carbonate in DMF (N,N-dimethyl-formamide) T=20°C; 24 h;
参考文献
PHARMACIA and UPJOHN COMPANY LLC
Patent: WO2005/82897 A1, 2005 ;
Location in patent: Page/Page column 29 ;
反应条件
NaH in tetrahydrofuran
参考文献
Allergan, Inc.
Patent: US5091528 A1, 1992 ;
US 5091528 A
反应条件
1: 98 percent / borane dimethyl sulfide / tetrahydrofuran / Heating 2: AcOH / 1 h / 20 °C 3: 1.21 g / NaBH3CN; AcOH / 20 °C 4: 75 percent / H2 / Pd/C / ethyl acetate; ethanol / 20 °C View Scheme
参考文献
Higuchi, Robert I.; Arienti, Kristen L.; Lopez, Francisco J.; Mani, Neelakhanda S.; Mais, Dale E.; Caferro, Thomas R.; Long, Yun Oliver; Jones, Todd K.; Edwards, James P.; Zhi, Lin; Schrader, William T.; Negro-Vilar, Andres; Marschke, Keith B.
Journal of Medicinal Chemistry, 2007 , vol. 50, # 10 p. 2486 - 2496
