6-硝基-2H-1,4-苯并噁嗪-3(4H)-酮合成路线 （共 18 条）
反应条件
potassium borohydride; copper(l) chloride in methanol T=25°C; 0.5 h;
参考文献
Bhat, Laxminarayan; Mohapatra, Prabhu Prasad; Adiey, Kouacou
Patent: US2010/216783 A1, 2010 ;
Location in patent: Page/Page column 14 ;
US 20100216783 A1
反应条件
borane-THF in tetrahydrofuran 0.666667 h;
参考文献
Szczepankiewicz, Bruce G.; Heathcock, Clayton H.
Tetrahedron, 1997 , vol. 53, # 26 p. 8853 - 8870
参考文献
Vertex Pharmaceuticals Incorported
Patent: US2011/98311 A1, 2011 ;
反应条件
1: 3-Oxo-6-nitro-3,4-dihydro-2H-1,4-benzoxazine With sodium hydride in N,N-dimethyl-formamide T=0°C; 0.166667 h; 2: methyl iodide in N,N-dimethyl-formamide T=0°C; 1 h;
参考文献
Berger, Jacob; Caroon, Joan Marie; Krauss, Nancy Elisabeth; Walker, Keith Adrian Murray; Zhao, Shu-Hai; Lopez-Tapia, Francisco Javier
Patent: US2010/160373 A1, 2010 ;
Location in patent: Page/Page column 30 ;
US 20100160373 A1
参考文献
Allergan, Inc.
Patent: US5091528 A1, 1992 ;
US 5091528 A
反应条件
1: 1) NaH / 1a) DMF, RT, 15 min, 1b) 50 to 60 deg C, 2) DMF, 100 deg C, 4 h 2: 79 percent / hydrazine hydrate / Raney nickel / ethanol / 2 h / Heating View Scheme
参考文献
Shridhar, D. R.; Rao, K. Srinivasa; Singh, A. N.; Rastogi, K.; Jain, M. L.; et al.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1985 , vol. 24, p. 1263 - 1267
反应条件
1.1: borane-THF / tetrahydrofuran / 2 h / |Reflux
1.2: 1 h / |Reflux
2.1: sodium hydrogencarbonate / dichloromethane / 0.5 h / 0 °C
2.2: 2 h / 20 °C
3.1: palladium 10 on activated carbon; hydrogen / methanol; tetrahydrofuran / 2 h / 20 °C
View Scheme
参考文献
Lee, Jeewoo; Tran, Phuong-Thao; Hoang, Van-Hai; Thorat, Shivaji A.; Kim, Sung Eun; Ann, Jihyae; Chang, Yu Jin; Nam, Dong Woo; Song, Hyundong; Mook-Jung, Inhee; Lee, Jiyoun
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 13 p. 3821 - 3830
反应条件
1.1: borane-THF / tetrahydrofuran / 2 h / |Reflux
1.2: 1 h / |Reflux
2.1: sodium hydrogencarbonate / dichloromethane / 0.5 h / 0 °C
2.2: 2 h / 20 °C
View Scheme
参考文献
Lee, Jeewoo; Tran, Phuong-Thao; Hoang, Van-Hai; Thorat, Shivaji A.; Kim, Sung Eun; Ann, Jihyae; Chang, Yu Jin; Nam, Dong Woo; Song, Hyundong; Mook-Jung, Inhee; Lee, Jiyoun
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 13 p. 3821 - 3830
