5-(溴乙酰基)-1,3-亚苯基二(二甲基氨基甲酸酯)合成路线 （共 2 条）
反应条件
1: pyridine; potassium carbonate sesquihydrate; potassium carbonate / water; ethyl acetate / 3.5 h / 70 °C
2: copper(I) bromide / chloroform; ethyl acetate / 5 h / Reflux
View Scheme
参考文献
Bosak, Anita; Smilovic, Ivana Gazic; Sinko, Goran; Vinkovic, Vladimir; Kovarik, Zrinka
Journal of Medicinal Chemistry, 2012 , vol. 55, # 15 p. 6716 - 6723
反应条件
1: immobilized Burkholderia cepacia lipase (Amano PS-IM) / isopropyl alcohol; tetrahydrofuran / 60 h / 20 °C / |Inert atmosphere; |Enzymatic reaction
2: potassium carbonate / N,N-dimethyl-formamide / 6.5 h / 20 °C
3: bromine / acetic acid / 1.17 h / 0 - 20 °C
View Scheme
参考文献
Asami, Kento; Machida, Takuya; Jung, Sonna; Hanaya, Kengo; Shoji, Mitsuru; Sugai, Takeshi
Journal of Molecular Catalysis B: Enzymatic, 2013 , vol. 97, p. 106 - 109
