4-氯-2-甲基-5,6,7,8-四氢[1]苯并噻吩[2,3-D]嘧啶合成路线 （共 4 条）
反应条件
trichlorophosphate 3 h; Heating;
参考文献
Yamaguchi, Hitoshi; Ishikawa, Fumiyoshi
Chemical and Pharmaceutical Bulletin, 1982 , vol. 30, # 1 p. 326 - 332
反应条件
1: t-BuOK / 120 °C / microwave irradiation 2: POCl3 / 0.17 h / 120 °C / microwave irradiation View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 55, # 5 p. 776 - 779
反应条件
hydrazine hydrate in ethanol
2 h; Heating;
参考文献
Shishoo, C. J.; Devani, M. B.; Karvekar, M. D.; Ullas, G. V.; Ananthan, S.; et al.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1982 , vol. <B> 21, # 7 p. 666 - 668
反应条件
1: 88 percent / NH2NH2*H2O / ethanol / 2 h / Heating
2: 78 percent / aq. 2 / acetic acid / 5 °C
View Scheme
参考文献
Shishoo, C. J.; Devani, M. B.; Karvekar, M. D.; Ullas, G. V.; Ananthan, S.; et al.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1982 , vol. <B> 21, # 7 p. 666 - 668
