1-苄基-1H-吲哚-2-甲醛合成路线 （共 18 条）
反应条件
1: 1H-indole-2-carbaldehyde With sodium hydride in N,N-dimethyl-formamide; mineral oil
Cooling with ice;
2: benzyl bromide in N,N-dimethyl-formamide; mineral oil
T=20°C; Cooling with ice;
参考文献
Biswas, Subhasish; Singh, Virender; Batra, Sanjay
Tetrahedron, 2010 , vol. 66, # 39 p. 7781 - 7786
反应条件
1: N-benzyl-indole With n-butyllithium in diethyl ether
T=20°C; 3 h; Reflux;
2: N,N-dimethyl-formamide in diethyl ether
3 h; Reflux;
参考文献
Yang, Yan-Fang; Li, Lian-Hua; He, Yu-Tao; Luo, Jian-Yi; Liang, Yong-Min
Tetrahedron, 2014 , vol. 70, # 3 p. 702 - 707
反应条件
2,2'-azo-bisisobutyronitrile; tri-n-butyl-tin hydride in benzene
2 h; Heating;
参考文献
Bennasar, M.-Lluisa; Roca, Tomas; Ferrando, Francesc
Tetrahedron Letters, 2004 , vol. 45, # 29 p. 5605 - 5609
反应条件
manganese(IV) oxide; lithium aluminium tetrahydride
1.) THF, RT, 2.) CH2Cl2, RT; Yield given. Multistep reaction;
参考文献
Suzuki; Yokoyama; Miyagi; Murakami
Chemical and Pharmaceutical Bulletin, 1991 , vol. 39, # 8 p. 2170 - 2172
反应条件
1: KOH / methanol; dioxane / Heating
2: Et3N; PBu3 / tetrahydrofuran / 20 °C
3: 90 percent / n-Bu3SnH; AIBN / benzene / 2 h / Heating
View Scheme
参考文献
Bennasar, M.-Lluisa; Roca, Tomas; Ferrando, Francesc
Tetrahedron Letters, 2004 , vol. 45, # 29 p. 5605 - 5609
反应条件
2: 16.4 g / sodium hydride / hexamethylphosphoric acid triamide / 1.) 0 degC, 3 h, 2.) 0 degC to R.T., 2.5 h
3: 95 percent / hydrazine hydrate / ethanol / 3 h / Heating
4: 97 percent / pyridine / 1.) 0 degC, 0.5 h, 2.) 0 degC to R.T. 2 h
5: 1.6 g / potassium carbonate / ethane-1,2-diol / 150 °C
View Scheme
参考文献
Reed, G. W. Bryan; Cheng, Peter T. W.; McLean Stewart
Canadian Journal of Chemistry, 1982 , vol. 60, p. 419 - 424
反应条件
potassium carbonate in ethylene glycol
T=150°C;
参考文献
Reed, G. W. Bryan; Cheng, Peter T. W.; McLean Stewart
Canadian Journal of Chemistry, 1982 , vol. 60, p. 419 - 424
反应条件
1: 93 percent / NaH / tetrahydrofuran / 20 °C
2: KOH / methanol; dioxane / Heating
3: Et3N; PBu3 / tetrahydrofuran / 20 °C
4: 90 percent / n-Bu3SnH; AIBN / benzene / 2 h / Heating
View Scheme
参考文献
Bennasar, M.-Lluisa; Roca, Tomas; Ferrando, Francesc
Tetrahedron Letters, 2004 , vol. 45, # 29 p. 5605 - 5609
反应条件
1: Et3N; PBu3 / tetrahydrofuran / 20 °C
2: 90 percent / n-Bu3SnH; AIBN / benzene / 2 h / Heating
View Scheme
参考文献
Bennasar, M.-Lluisa; Roca, Tomas; Ferrando, Francesc
Tetrahedron Letters, 2004 , vol. 45, # 29 p. 5605 - 5609
反应条件
1: 93 percent / NaH / tetrahydrofuran / 20 °C
2: KOH / methanol; dioxane / Heating
3: Et3N; PBu3 / tetrahydrofuran / 20 °C
4: 90 percent / n-Bu3SnH; AIBN / benzene / 2 h / Heating
View Scheme
参考文献
Bennasar, M.-Lluisa; Roca, Tomas; Ferrando, Francesc
Tetrahedron Letters, 2004 , vol. 45, # 29 p. 5605 - 5609
