7-羟基-1,3-苯并间二氧杂环戊烯-5-甲醛合成路线 （共 6 条）
反应条件
potassium carbonate in acetone 6 h;
参考文献
Synthetic Communications, , vol. 11, # 12 p. 969 - 978
反应条件
1.1: 63 percent / K2CO3 / dimethylformamide / 3 h / 100 °C
2.1: toluene / 3.5 h / Heating
3.1: n-BuLi / diethyl ether; hexane / -78 °C
3.2: diethyl ether; hexane / -78 - 20 °C
4.1: H2O2 / methanol; H2O / 0.25 h
4.2: 0.91 g / aq. HCl / 100 °C
View Scheme
参考文献
Shaikh, Ajam C.; Wang, Yu-Yun; Chen, Chinpiao
Journal of Labelled Compounds and Radiopharmaceuticals, 2007 , vol. 50, # 7 p. 660 - 665
反应条件
1.1: toluene / 3.5 h / Heating
2.1: n-BuLi / diethyl ether; hexane / -78 °C
2.2: diethyl ether; hexane / -78 - 20 °C
3.1: H2O2 / methanol; H2O / 0.25 h
3.2: 0.91 g / aq. HCl / 100 °C
View Scheme
参考文献
Shaikh, Ajam C.; Wang, Yu-Yun; Chen, Chinpiao
Journal of Labelled Compounds and Radiopharmaceuticals, 2007 , vol. 50, # 7 p. 660 - 665
反应条件
1.1: 53 percent / Br2; acetic acid / 1.5 h / 30 °C
2.1: 63 percent / K2CO3 / dimethylformamide / 3 h / 100 °C
3.1: toluene / 3.5 h / Heating
4.1: n-BuLi / diethyl ether; hexane / -78 °C
4.2: diethyl ether; hexane / -78 - 20 °C
5.1: H2O2 / methanol; H2O / 0.25 h
5.2: 0.91 g / aq. HCl / 100 °C
View Scheme
参考文献
Shaikh, Ajam C.; Wang, Yu-Yun; Chen, Chinpiao
Journal of Labelled Compounds and Radiopharmaceuticals, 2007 , vol. 50, # 7 p. 660 - 665
反应条件
n-butyllithium; nitrobenzene
1.) THF, hexane, -75 deg C, 50 min.; 2.) -75 deg C, 4h, -> room temp.; Yield given. Multistep reaction;
参考文献
Sinhababu, Achintya K.; Borchardt, Ronald T.
Journal of Organic Chemistry, 1983 , vol. 48, # 12 p. 1941 - 1944
反应条件
ammonium sulfate; n-butyllithium; tributoxyborane; dihydrogen peroxide
Yield given. Multistep reaction;
参考文献
Jacob, Peyton; Shulgin, Alexander T.
Synthetic Communications, 1981 , vol. 11, # 12 p. 969 - 978
