3-溴-6-甲氧基-2,4-二甲基吡啶合成路线 （共 5 条）
反应条件
silver carbonate in chloroform
T=10 - 35°C; 36 h;
参考文献
EISAI RandD MANAGEMENT CO., LTD.; Norimine, Yoshihiko; Takeda, Kunitoshi; Hagiwara, Koji; Suzuki, Yuichi; Ishihara, Yuki; Sato, Nobuaki
Patent: US2013/143907 A1, 2013 ;
Location in patent: Paragraph 0397; 0398; 0399 ;
反应条件
in methanol; N,N-dimethyl-formamide
T=60°C; 15 h;
参考文献
EISAI RandD MANAGEMENT CO., LTD.; Norimine, Yoshihiko; Takeda, Kunitoshi; Hagiwara, Koji; Suzuki, Yuichi; Ishihara, Yuki; Sato, Nobuaki
Patent: US2013/143907 A1, 2013 ;
Location in patent: Paragraph 0392; 0393 ;
反应条件
1.1: sodium nitrite; hypophosphorous acid / H2O / 12 h / 20 °C
1.2: 87 percent / water / 6 h / 5 °C / pH 6 - 7
2.1: 90 percent / silver carbonate / CH2Cl2 / 24 h
View Scheme
参考文献
Wijtmans, Maikel; Pratt, Derek A.; Brinkhorst, Johan; Serwa, Remigiusz; Valgimigli, Luca; Pedulli, Gian Franco; Porter, Ned A.
Journal of Organic Chemistry, 2004 , vol. 69, # 26 p. 9215 - 9223
反应条件
1.1: 67 percent / 1,3-dibromo-5,5-dimethylhydantoin / CH2Cl2 / 0.75 h / -40 °C
2.1: sodium nitrite; hypophosphorous acid / H2O / 12 h / 20 °C
2.2: 87 percent / water / 6 h / 5 °C / pH 6 - 7
3.1: 90 percent / silver carbonate / CH2Cl2 / 24 h
View Scheme
参考文献
Wijtmans, Maikel; Pratt, Derek A.; Brinkhorst, Johan; Serwa, Remigiusz; Valgimigli, Luca; Pedulli, Gian Franco; Porter, Ned A.
Journal of Organic Chemistry, 2004 , vol. 69, # 26 p. 9215 - 9223
反应条件
1.1: n-BuLi / tetrahydrofuran; hexane / 1 h / -78 °C
1.2: 89 percent / tetrahydrofuran; hexane / 0.5 h / -78 °C
2.1: m-CPBA; p-toluenesulfonic acid / CHCl3 / 24 h / 20 °C
3.1: 0.15 g / KOH / methanol / 2 h / Heating
View Scheme
参考文献
Wijtmans, Maikel; Pratt, Derek A.; Brinkhorst, Johan; Serwa, Remigiusz; Valgimigli, Luca; Pedulli, Gian Franco; Porter, Ned A.
Journal of Organic Chemistry, 2004 , vol. 69, # 26 p. 9215 - 9223
