[1R-(2-endo,3-exo)]-3-羟基-4,7,7-三甲基双环[2.2.1]庚烷-2-乙酸合成路线 （共 16 条）
反应条件
potassium hydroxide in methanol T=50°C;
参考文献
Noe, Christian R.
Chemische Berichte, 1982 , vol. 115, # 4 p. 1576 - 1590
反应条件
sodium hydroxide; hydrogen; palladium on activated charcoal P=3000.2 Torr; 3 h;
参考文献
Liebigs Annales, , # 6 p. 1015 - 1021
反应条件
sodium hydroxide; sodium tetrahydroborate in ethanol T=50°C; 16 h; EtOH, Na, 5 h;
参考文献
Chemische Berichte, , vol. 115, # 4 p. 1576 - 1590
反应条件
1: 1.) NaH / 1.) xylene, reflux, 4 h, 2.) r.t., 12 h 2: 90 percent / aq. KOH / ethanol / 3 h / Ambient temperature 3: NaBH4, aq. NaOH / ethanol / 5 h / Heating 4: 20 percent / H2, 1 M aq. NaOH / 10percent Pd/C / 3 h / 3000.2 Torr View Scheme
参考文献
Liebigs Annales, , # 6 p. 1015 - 1021
反应条件
1: NaBH4, aq. NaOH / ethanol / 5 h / Heating 2: 20 percent / H2, 1 M aq. NaOH / 10percent Pd/C / 3 h / 3000.2 Torr View Scheme
参考文献
Liebigs Annales, , # 6 p. 1015 - 1021
反应条件
1: 1) NaBH4, 2) pyridine / 1) EtOH, 4 h, r.t., 2) CH2Cl2, 5 h, r.t. 2: 94 percent / Na2Cr2O7, conc. H2SO4 / diethyl ether; H2O / 2 h / 25 °C 3: 77 percent / dimethylsulfoxide / 70 °C 4: 88 percent / HCl / 12 h / 4 °C 5: 24 percent / NaBH4 / ethanol / 16 h / 40 °C 6: 98 percent / 2 N KOH / methanol / 50 °C View Scheme
参考文献
Chemische Berichte, , vol. 115, # 4 p. 1576 - 1590
反应条件
1: 1) NaBH4, BF3*Et2O, 2) pyridine / 1) THF, 17 h, 25 deg C, 2) CH2Cl2, 5 h, r.t. 2: 94 percent / Na2Cr2O7, conc. H2SO4 / diethyl ether; H2O / 2 h / 25 °C 3: 77 percent / dimethylsulfoxide / 70 °C 4: 88 percent / HCl / 12 h / 4 °C 5: 24 percent / NaBH4 / ethanol / 16 h / 40 °C 6: 98 percent / 2 N KOH / methanol / 50 °C View Scheme
参考文献
Chemische Berichte, , vol. 115, # 4 p. 1576 - 1590
反应条件
1: 50 percent / dimethylsulfoxide / 2 h / 70 °C 2: 94 percent / Na2Cr2O7, conc. H2SO4 / diethyl ether; H2O / 25 °C 3: 88 percent / HCl / 12 h / 4 °C 4: 24 percent / NaBH4 / ethanol / 16 h / 40 °C 5: 98 percent / 2 N KOH / methanol / 50 °C View Scheme
参考文献
Chemische Berichte, , vol. 115, # 4 p. 1576 - 1590
反应条件
1: 94 percent / Na2Cr2O7, conc. H2SO4 / diethyl ether; H2O / 2 h / 25 °C 2: 77 percent / dimethylsulfoxide / 70 °C 3: 88 percent / HCl / 12 h / 4 °C 4: 24 percent / NaBH4 / ethanol / 16 h / 40 °C 5: 98 percent / 2 N KOH / methanol / 50 °C View Scheme
参考文献
Chemische Berichte, , vol. 115, # 4 p. 1576 - 1590
反应条件
1: 88 percent / HCl / 12 h / 4 °C 2: 24 percent / NaBH4 / ethanol / 16 h / 40 °C 3: 98 percent / 2 N KOH / methanol / 50 °C View Scheme
参考文献
Chemische Berichte, , vol. 115, # 4 p. 1576 - 1590
