2,3,6,7-四氢呋喃并[2,3-f][1]苯并呋喃合成路线 （共 8 条）
反应条件
1: AlCl3 / CH2Cl2 / 16 h 2: 92 percent / TFA; Et3SiH / 6 h / Heating 3: 64 percent / DDQ / dioxane / 24 h / Heating View Scheme
参考文献
Chambers; Kurrasch-Orbaugh; Parker; Nichols
Journal of Medicinal Chemistry, 2001 , vol. 44, # 6 p. 1003 - 1010
反应条件
tin(IV) chloride in dichloromethane 0.5 h;
参考文献
Monte, Aaron P.; Marona-Lewicka, Danuta; Parker, Matthew A.; Wainscott, David B.; Nelson, David L.; Nichols, David E.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 15 p. 2953 - 2961
反应条件
n-butyllithium in tetrahydrofuran; hexane
0.166667 h;
参考文献
Monte, Aaron P.; Marona-Lewicka, Danuta; Parker, Matthew A.; Wainscott, David B.; Nelson, David L.; Nichols, David E.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 15 p. 2953 - 2961
反应条件
1: 91 percent / Br2; ZnCl2 / acetic acid
2: 79 percent / Mg; EtMgBr / tetrahydrofuran / 3 h / Heating
View Scheme
参考文献
Chambers; Kurrasch-Orbaugh; Parker; Nichols
Journal of Medicinal Chemistry, 2001 , vol. 44, # 6 p. 1003 - 1010
反应条件
1: 88 percent / SOCl2; pyridine / 20 °C
2: 91 percent / Br2; ZnCl2 / acetic acid
3: 79 percent / Mg; EtMgBr / tetrahydrofuran / 3 h / Heating
View Scheme
参考文献
Chambers; Kurrasch-Orbaugh; Parker; Nichols
Journal of Medicinal Chemistry, 2001 , vol. 44, # 6 p. 1003 - 1010
反应条件
1: 32 percent / K2CO3 / acetone / 24 h / Heating
2: 92 percent / Fe, Br2 / CCl4 / 4.5 h / Ambient temperature
3: 80 percent / n-BuLi / tetrahydrofuran; hexane / 0.17 h
View Scheme
参考文献
Monte, Aaron P.; Marona-Lewicka, Danuta; Parker, Matthew A.; Wainscott, David B.; Nelson, David L.; Nichols, David E.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 15 p. 2953 - 2961
反应条件
sodium hydride in dimethyl sulfoxide
1.) room temperature, 1.5 h, 2.) 60 deg C, 4 h;
参考文献
Blade-Font, Artur; Rocabayera, Teodoro de Mas
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1982 , p. 841 - 848
反应条件
1: 97 percent / CH2Cl2 / 24 h / Ambient temperature
2: 27 percent / 1.) NaH / dimethylsulfoxide / 1.) room temperature, 1.5 h, 2.) 60 deg C, 4 h
View Scheme
参考文献
Blade-Font, Artur; Rocabayera, Teodoro de Mas
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1982 , p. 841 - 848
