2,2,2-三氯乙酰胺苄酯合成路线 （共 52 条）
反应条件
trifluorormethanesulfonic acid; 4 A molecular sieve in 1,4-dioxane
T=20°C; 0.0833333 h;
参考文献
Hansen, Flemming Gundorph; Bundgaard, Eva; Madsen, Robert
Journal of Organic Chemistry, 2005 , vol. 70, # 24 p. 10139 - 10142
反应条件
1: 1-O-methyl-α,β-D-arabinofuranoside With pyridine; p-toluenesulfonyl chloride
T=20°C; 48 h;
2: 2,2,2-trichloro-1-(phenylmethoxy)ethanimine With trifluorormethanesulfonic acid in 1,4-dioxane
T=20°C;
3: With sodium iodide in ethylene glycol dimethyl ether
T=90°C; 48 h;
参考文献
Goumain, Sophie; Taghzouti, Hanaa; Portella, Charles; Behr, Jean-Bernard; Plantier-Royon, Richard
Tetrahedron Letters, 2012 , vol. 53, # 33 p. 4440 - 4443
反应条件
1: 74 percent / trifluoromethanesulfonic acid / CH2Cl2 / 2 h / 0 °C
2: 80 percent / zinc dust / acetic acid / 3 h / 50 °C
View Scheme
参考文献
Imoto, Masahiro; Yoshimura, Hiroyuki; Yamamoto, Michiharu; Shimamoto, Tetsuo; Kusumoto, Shoichi; Shiba, Tetsuo
Bulletin of the Chemical Society of Japan, 1987 , vol. 60, p. 2197 - 2204
反应条件
trifluorormethanesulfonic acid in dichloromethane; cyclohexane
T=20°C; 1 h;
参考文献
Gefflaut; Martin; Delor; Besse; Veschambre; Bolte
Journal of Organic Chemistry, 2001 , vol. 66, # 7 p. 2296 - 2301
反应条件
1: 78 percent / CF3SO3H / hexane; CH2Cl2 / 0.42 h / Heating
2: diisobutylaluminum hydride / diethyl ether; hexane / 1.) -78 deg C, 25 min, 2.) 0 deg C, 2 h, then 25 deg C, 2 h
View Scheme
参考文献
Balasubramaniam, Rajiv P.; Moss, David K.; Wyatt, Justin K.; Spence, John D.; Gee, Arvin; Nantz, Michael H.
Tetrahedron, 1997 , vol. 53, # 22 p. 7429 - 7444
反应条件
trifluorormethanesulfonic acid in dichloromethane; cyclohexane
Ambient temperature; Yield given;
参考文献
Leder; Fujioka; Kishi
Tetrahedron Letters, 1983 , vol. 24, # 14 p. 1463 - 1466
反应条件
1: 37 percent / triflic acid / CH2Cl2; tetrahydrofuran / 0.83 h / Ambient temperature
2: 72 percent / 0.1 N NaOEt / 2 h / Ambient temperature
3: 1.) pyridine, DMF, copper powder, 4-dimethylaminopyridine / 1.) < -70 to 115 deg C; sealed tube, 2.) 8 h, 60 deg C; sealed tube was opened
View Scheme
参考文献
Yamashita; Matsumotot; Kobayashi; Noguchi; Yasumoto; Ueda
Chemical and Pharmaceutical Bulletin, 1989 , vol. 37, # 9 p. 2287 - 2292
反应条件
trifluorormethanesulfonic acid in dichloromethane; cyclohexane
18 h; Ambient temperature;
参考文献
Liu; Coward
Journal of Medicinal Chemistry, 1991 , vol. 34, # 7 p. 2094 - 2101
反应条件
trifluorormethanesulfonic acid in 1,4-dioxane
pH 3;
参考文献
Jensen, Hanne Stampe; Limberg, Gerrit; Pedersen, Christian
Carbohydrate Research, 1997 , vol. 302, # 1-2 p. 109 - 112
反应条件
1.1: trifluorormethanesulfonic acid / dichloromethane; cyclohexane / 48 h / 0 - 20 °C
2.1: cerium(III) chloride heptahydrate / tetrahydrofuran / 1 h / -78 °C / |Inert atmosphere
2.2: 20 °C
3.1: amberlyst 15 / hexane / 1 h / 20 °C
View Scheme
参考文献
Fleury, Etienne; Sorin, Geoffroy; Prost, Elise; Pancrazi, Ange; Sautel, Francois; Massiot, Georges; Lannou, Marie-Isabelle; Ardisson, Janick
Journal of Organic Chemistry, 2013 , vol. 78, # 3 p. 855 - 864
