7-氟-2,3-二氢-1,4-苯并二噁英-5-羧酸甲酯合成路线 （共 2 条）
反应条件
1: C8H7FO4 With caesium carbonate in N,N-dimethyl-formamide
T=20°C; 0.5 h;
2: ethylene dibromide in N,N-dimethyl-formamide
T=80°C; 16 h;
参考文献
Xu, Rong; Hong, Jinsoo; Morse, Cheryl L.; Pike, Victor W.
Journal of Medicinal Chemistry, 2010 , vol. 53, # 19 p. 7035 - 7047
反应条件
lithium hydroxide; water in tetrahydrofuran
T=20°C;
参考文献
JANSSEN PHARMACEUTICA N.V.
Patent: WO2005/837 A1, 2005 ;
Location in patent: Page 24 ;
WO 2005/000837 A1
