咪唑并[1,2-A]吡啶-2-甲醇合成路线 （共 5 条）
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran T=5°C; 2 h; Cooling with ice; 2: With water in tetrahydrofuran
参考文献
Sunovion Pharmaceuticals Inc.
Patent: US2012/178748 A1, 2012 ;
Location in patent: Page/Page column 49 ;
US 20120178748 A1
反应条件
sodium methylate in methanol 0.75 h;
参考文献
WO2009/140553 A2, ;
Page/Page column 63 ;
反应条件
1: ethanol / 5 h / Heating 2: LiAlH4 / CH2Cl2; diethyl ether / 1 h / Heating View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 25, # 1 p. 129 - 137
反应条件
manganese(IV) oxide in chloroform; acetonitrile 22 h;
参考文献
WO2007/87548 A2, ;
Page/Page column 47 ;
WO 2007/087548 A2
反应条件
1: 61 percent / cc. H2SO4; HNO3 / 4 h / 20 °C
2: 92 percent / manganese oxide / CHCl3 / 4 h / Heating
3: 0.98 g / SiO2 / CH2Cl2
4: 53 percent / tin powder; aq. HBr / 2 h / 0 °C
5: 67 percent / KOH / ethanol / 4 h / Heating
View Scheme
参考文献
Desbois, Nicolas; Chezal, Jean-Michel; Fauvelle, Florence; Debouzy, Jean-Claude; Lartigue, Claire; Gueiffier, Alain; Blache, Yves; Moreau, Emmanuel; Madelmont, Jean-Claude; Chavignon, Olivier; Teulade, Jean-Claude
Heterocycles, 2005 , vol. 65, # 5 p. 1121 - 1137
