叔-丁基3-[甲氧基(甲基)氨基甲酰]吖丁啶-1-羧酸酯合成路线 （共 5 条）
反应条件
1: 3-carboxyazetidine-1-carboxylic acid tert-butyl ester With dicyclohexyl-carbodiimide in tetrahydrofuran
T=20°C;
2: O,N-dimethyl-hydroxylamine hydrochloride With triethylamine in tetrahydrofuran; acetonitrile
T=20°C; 24 h;
参考文献
PFIZER LIMITED; ACIRO, Caroline; BAGAL, Sharanjeet Kaur; HARVEY, John Wilson; JONES, Lyn Howard; MOWBRAY, Charles Eric; OWEN, Robert McKenzie; SABNIS, Yogesh Anil; STORER, Robert Ian; YEAP, Siew Kuen
Patent: WO2010/131145 A1, 2010 ;
Location in patent: Page/Page column 86 ;
反应条件
1: 3-carboxyazetidine-1-carboxylic acid tert-butyl ester With N-ethyl-N,N-diisopropylamine; 1,1'-carbonyldiimidazole in tetrahydrofuran
T=20°C; 0.5 h;
2: N,O-dimethyl-hydroxylamine in tetrahydrofuran
T=20°C; 15 h;
参考文献
GAWECO, Anderson; WALKER, John; MONAHAN, Joseph, B.; CUBBAGE, Jerry, W.; CARROLL, Jeffery
Patent: WO2012/9649 A1, 2012 ;
Location in patent: Page/Page column 92-93 ;
反应条件
1: in tetrahydrofuran; toluene
T=0 - 20°C; 3.66667 h;
2: With water; citric acid
T=0°C;
参考文献
Pfizer Inc.
Patent: US2010/190771 A1, 2010 ;
Location in patent: Page/Page column 31-32 ;
反应条件
1: in diethyl ether
T=0°C; 2 h;
2: With hydrogenchloride in diethyl ether; water
参考文献
Proskelia SAS
Patent: US2008/58348 A1, 2008 ;
Location in patent: Page/Page column 13 ;
反应条件
in tetrahydrofuran
T=0°C; 1 h;
参考文献
MERCK and CO., INC.; NEUROMED PHARMACEUTICALS LTD.
Patent: WO2009/45382 A1, 2009 ;
Location in patent: Page/Page column 53 ;
WO 2009/045382 A1
