反式-1,4-二溴-2-丁烯合成路线 （共 96 条）
反应条件
1: 1,4-trans-dibromo-2-butene With copper(I) thiophene-2-carboxylate; (S)-(-)-N-(2,2-dimethylpropionyl)-2-lt;(diphenylphosphino)methylgt;pyrrolidine in dichloromethane Inert atmosphere; 2: phenyl-magnesium bromide in diethyl ether; dichloromethane T=-78°C; Inert atmosphere; optical yield given as percent eeenantioselective reaction;
参考文献
Selim, Khalid B.; Yamada, Ken-Ichi; Tomioka, Kiyoshi
Chemical Communications, 2008 , # 41 p. 5140 - 5142
反应条件
in diethyl ether 24 h; Ambient temperature;
参考文献
Mesnard,D.; Miginiac,L.
Comptes Rendus des Seances de l'Academie des Sciences, Serie C: Sciences Chimiques, 1973 , vol. 277, p. 567 - 570
反应条件
sodium acetate in N-methyl-acetamide
参考文献
Hoffmann-La Roche Inc.
Patent: US3963777 A1, 1976 ;
反应条件
in acetic acid Heating;
参考文献
Yoo, Sung-Eun; Lee, Sang-Hee; Yi, Kyu-Yang; Jeong, Nakcheol
Tetrahedron Letters, 1990 , vol. 31, # 47 p. 6877 - 6880
反应条件
potassium carbonate in ethanol 12.75 h; Heating;
参考文献
Bowman, Roy K.; Johnson, Jeffrey S.
Organic Letters, 2006 , vol. 8, # 4 p. 573 - 576
参考文献
Kierstead et al.
Journal of the Chemical Society, 1953 , p. 1803,1806
反应条件
n-butyllithium 1.) toluene, hexan, 15 min, r.t.; 2.) toluene, reflux, 22 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Bigi, Franca; Casiraghi, Giovanni; Casnati, Giuseppe; Sartori, Giovanni
Tetrahedron, 1983 , vol. 39, # 1 p. 169 - 174
反应条件
reaction with alkali phenolates, effect of the cation on the reaction conditions; MechanismProduct distribution;
参考文献
Bigi, Franca; Casiraghi, Giovanni; Casnati, Giuseppe; Sartori, Giovanni
Tetrahedron, 1983 , vol. 39, # 1 p. 169 - 174
反应条件
in acetic acid 24 h; Heating;
参考文献
Bouquillon, Sandrine; Muzart, Jacques
European Journal of Organic Chemistry, 2001 , # 17 p. 3301 - 3305
反应条件
potassium acetate in acetic acid
参考文献
Heasley,V.L.; Chamberlain,P.H.
Journal of Organic Chemistry, 1970 , vol. 35, p. 539 - 541
