反式-1,4-二溴-2-丁烯合成路线 （共 96 条）
反应条件
1,8-diazabicyclo[5.4.0]undec-7-ene in benzene
T=0 - 20°C; 1 h;
参考文献
Yamada, Takumasa; Yoshimura, Fumihiko; Tanino, Keiji
Tetrahedron Letters, 2013 , vol. 54, # 6 p. 522 - 525
参考文献
Kierstead et al.
Journal of the Chemical Society, 1953 , p. 1803,1806
参考文献
Kierstead et al.
Journal of the Chemical Society, 1953 , p. 1803,1806
参考文献
Kharasch et al.
Journal of Organic Chemistry, 1955 , vol. 20, p. 1550,1552,1556
反应条件
1: With sodium azide in dimethyl sulfoxide
T=20°C; 72 h;
2: With ozone in methanol; diethyl ether; dichloromethane
T=-78°C;
3: With dimethylsulfide in methanol; diethyl ether; dichloromethane
Further stages.;
参考文献
Sugiyama, Masakazu; Hong, Zhangyong; Liang, Pi-Hui; Dean, Stephen M.; Whalen, Lisa J.; Greenberg, William A.; Wong, Chi-Huey
Journal of the American Chemical Society, 2007 , vol. 129, # 47 p. 14811 - 14817
反应条件
sodium hydride in tetrahydrofuran
T=0 - 20°C;
参考文献
Shibata, Takanori; Kurokawa, Hiroshi; Kanda, Kazumasa
Journal of Organic Chemistry, 2007 , vol. 72, # 17 p. 6521 - 6525
反应条件
sodium hydride in tetrahydrofuran; hexane
9 h; Ambient temperature;
参考文献
Saicic, Radomir N.; Matovic, Radomir; Cekovic, Zivorad
Gazzetta Chimica Italiana, 1991 , vol. 121, # 7 p. 325 - 328
反应条件
1: With lithium tert-butylate in toluene
T=20°C; 1 h;
2: With hydrogenchloride in tert-butyl methyl ether; water; toluene
T=20°C; 2 h;
3: With sodium hydroxide in tert-butyl methyl ether; water; toluene
T=0°C; pH=14;
参考文献
Bristol-Myers Squibb Company
Patent: US2009/274652 A1, 2009 ;
Location in patent: Page/Page column 23 ;
US 20090274652 A1
反应条件
1: With lithium tert-butylate in toluene
1 h;
2: With water in tert-butyl methyl ether; toluene
3: With hydrogenchloride in tert-butyl methyl ether; water
T=20°C; 2 h;
参考文献
Bristol-Myers Squibb Company
Patent: US2007/93414 A1, 2007 ;
Location in patent: Page/Page column 34 ;
参考文献
Wislicenus; Bruce
Chemische Berichte, 1907 , vol. 40, p. 3994
