1,4-二氯-2-丁炔合成路线 （共 101 条）
反应条件
1) CuCN*2LiBr
1) THF, -20 deg C, 15 min, 2) a) 0 deg C, 30 min, b) room temperature, 1 h; Yield given. Multistep reaction;
参考文献
Zhu, Lishan; Rieke, Reuben D.
Tetrahedron Letters, 1991 , vol. 32, # 25 p. 2865 - 2866
参考文献
Biel; Di Pierro
Journal of the American Chemical Society, 1958 , vol. 80, p. 4609,4611
Full Text Show Details
Reppe et al.
Justus Liebigs Annalen der Chemie, 1955 , vol. 596, p. 65
反应条件
1: 1,4-Dichloro-2-butyne; methyl iodide With Iron (III) nitrate nonahydrate; ammonia; sodium
T=-40°C; 3.5 h;
2: formaldehyd With sodium amide in tetrahydrofuran
T=-40°C; 3.5 h;
3: With ammonium chloride in tetrahydrofuran
参考文献
Bowling, Nathan P.; Burrmann, Nicola J.; Halter, Robert J.; Hodges, Jonathan A.; McMahon, Robert J.
Journal of Organic Chemistry, 2010 , vol. 75, # 19 p. 6382 - 6390
反应条件
ammonia; sodium amide
anschliessendes Behandeln mit einem Gemisch von Paraformaldehyd und Jodmethan;
参考文献
Armitage; Whiting
Journal of the Chemical Society, 1952 , p. 2005,2009
反应条件
ammonia; sodium amide
anschliessendes Behandeln mit einem Gemisch von Aceton und Jodmethan;
参考文献
Armitage; Whiting
Journal of the Chemical Society, 1952 , p. 2005,2009
反应条件
potassium fluoride; ethylene glycol
T=120°C;
参考文献
Pattison; Norman
Journal of the American Chemical Society, 1957 , vol. 79, p. 2311,2315
反应条件
potassium fluoride; ethylene glycol
T=120°C;
参考文献
Pattison; Norman
Journal of the American Chemical Society, 1957 , vol. 79, p. 2311,2315
反应条件
Me2S*BH2Br; methyllithium; diisobutylaluminium hydride
1.) CH2Cl2, 25 deg C, 2 h, 2.) hexane, 0 deg C, 3 h; room temperature, 2 h, 3.) Et2O, 0 deg C, 1 h; Yield given. Multistep reaction;
参考文献
Hoshi, Masayuki; Arase, Akira
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1993 , # 22 p. 2693 - 2700
反应条件
potassium hydroxide in ethanol
参考文献
Thyagarajan,B.S. et al.
Journal of Heterocyclic Chemistry, 1975 , vol. 12, p. 59 - 66
反应条件
(i) KOH, (ii) aq. H2O2, AcOH; Multistep reaction;
参考文献
Thyagarajan,B.S. et al.
Journal of Heterocyclic Chemistry, 1975 , vol. 12, p. 59 - 66
