1,4-二氯-2-丁炔合成路线 （共 101 条）
反应条件
sodium ethanolate in ethanol 2 h; Heating;
参考文献
Curran, Timothy P.; Keaney, Meghan T.
Journal of Organic Chemistry, 1996 , vol. 61, # 25 p. 9068 - 9069
反应条件
(i) Na, NH3, (ii) /BRN= 635740/, Et2O; Multistep reaction;
参考文献
van Boom,J.H. et al.
Recueil des Travaux Chimiques des Pays-Bas, 1966 , vol. 85, p. 580 - 600
反应条件
1: 1,4-Dichloro-2-butyne With lithium amide; iron nitrate (III) in ammonia T=-50°C; 1 h; 2: acrolein in ammonia 2 h; Further stages.;
参考文献
Mayer, Sandra F.; Steinreiber, Andreas; Orru, Romano V. A.; Faber, Kurt
Journal of Organic Chemistry, 2002 , vol. 67, # 26 p. 9115 - 9121
反应条件
in N,N-dimethyl-formamide T=100°C; 2 h;
参考文献
Jeon, Heung-Bae; Lee, Younghee; Qiao, Chunhua; Huang, He; Sayre, Lawrence M.
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 21 p. 4631 - 4641
反应条件
potassium carbonate in N,N-dimethyl-formamide T=80°C; 5 h;
参考文献
TAKEDA PHARMACEUTICAL COMPANY LIMITED; MATSUMOTO, Shigemitsu; ONO, Koji; TOMINARI, Yusuke; KATOH, Taisuke; MIWA, Kazuhiro; HASUOKA, Atsushi; IMAMURA, Shinichi
Patent: WO2013/18929 A1, 2013 ;
Location in patent: Paragraph 0456 ;
WO 2013/018929 A1
参考文献
Lewina et al.
Zhurnal Obshchei Khimii, 1950 , vol. 20, p. 294,297; engl.Ausg.S.313
反应条件
diethyl ether; copper(l) chloride
参考文献
Nigam; Weedon
Journal of the Chemical Society, 1957 , p. 3868,3872
参考文献
Lewina et al.
Zhurnal Obshchei Khimii, 1950 , vol. 20, p. 294,297; engl.Ausg.S.313
反应条件
1: 1,2-oxazolidin-3-one With potassium carbonate in acetone 1 h; Heating; 2: 1,4-Dichloro-2-butyne in acetone 24 h; Heating;
参考文献
Dallanoce, Clelia; Conti, Paola; De Amici, Marco; De Micheli, Carlo; Barocelli, Elisabetta; Chiavarini, Milena; Ballabeni, Vigilio; Bertoni, Simona; Impicciatore, Mariannina
Bioorganic and Medicinal Chemistry, 1999 , vol. 7, # 8 p. 1539 - 1547
反应条件
potassium carbonate in acetone Heating;
参考文献
Disingrini, Teresa; Muth, Mathias; Dallanoce, Clelia; Barocelli, Elisabetta; Bertoni, Simona; Kellershohn, Kerstin; Mohr, Klaus; De Amici, Marco; Holzgrabe, Ulrike
Journal of Medicinal Chemistry, 2006 , vol. 49, # 1 p. 366 - 372
