二(2-氯乙基)胺盐酸盐合成路线 （共 164 条）
反应条件
potassium carbonate in chlorobenzene RefluxInert atmosphere;
参考文献
Sun, Aiming; Moore, Terry W.; Gunther, Jillian R.; Kim, Mi-Sun; Rhoden, Eric; Du, Yuhong; Fu, Haian; Snyder, James P.; Katzenellenbogen, John A.
ChemMedChem, 2011 , vol. 6, # 4 p. 654 - 666
反应条件
in 2-(2-methoxy-ethoxy)-ethanol T=130°C; 24 h; Inert atmosphere;
参考文献
Weng, Zhiyong; Gao, Yanping; Zhang, Jiankang; Dong, Xiaowu; Liu, Tao
Journal of Chemical Research, 2011 , vol. 35, # 1 p. 43 - 46
反应条件
1: ethyl 2-mercaptoethyl sulfide With sodium in ethanol Heating; 2: bis-(2-chloroethyl)-amine hydrochloride in ethanol 4 h; Heating;
参考文献
Zeng, Li; Miller, Evan W.; Pralle, Arnd; Isacoff, Ehud Y.; Chang, Christopher J.
Journal of the American Chemical Society, 2006 , vol. 128, # 1 p. 10 - 11
反应条件
triethylamine in dichloromethane T=0 - 5°C; 2.16667 h;
参考文献
Li, Shan; Li, He-Ping; Qin, Long
Research on Chemical Intermediates, 2013 , vol. 39, # 5 p. 1949 - 1956
反应条件
pyridine; chloroform
参考文献
Brintzinger; Pfannstiel; Koddebusch
Chemische Berichte, 1949 , vol. 82, p. 389,397
反应条件
in various solvent(s) T=150°C;
参考文献
Liu, Kevin G.; Robichaud, Albert J.
Tetrahedron Letters, 2005 , vol. 46, # 46 p. 7921 - 7922
反应条件
lithium hydroxide in tetrahydrofuran 168 h; Heating;
参考文献
Habata, Yoichi; Seo, Joobeom; Otawa, Satoshi; Osaka, Futoshi; Noto, Kanae; Lee, Shim Sung
Dalton Transactions, 2006 , # 18 p. 2202 - 2206
反应条件
sodium hydroxide; sodium carbonate in dichloromethane
参考文献
McNeilab, Inc.
Patent: US4992441 A1, 1991 ;
反应条件
T=20 - 165°C; neat (no solvent);
参考文献
Konstantinova, Igor; Bukhryakov, Konstantin; Gezentsvey, Yuri; Krasavin, Mikhail
Letters in Organic Chemistry, 2011 , vol. 8, # 9 p. 628 - 630
反应条件
sodium carbonate 1, 2) n-BuOH, reflux; Yield given. Multistep reaction;
参考文献
Martin; Elgin Jr.; Mathiasen; Davis; Kesslick; Baldy; Shank; DiStefano; Fedde; Scott
Journal of Medicinal Chemistry, 1989 , vol. 32, # 5 p. 1052 - 1056
