二(2-氯乙基)胺盐酸盐合成路线 （共 164 条）
反应条件
sodium hydrogencarbonate in ethanol
参考文献
Kuwada,Y.
Chemical and Pharmaceutical Bulletin, 1960 , vol. 8, p. 807 - 814
反应条件
T=20 - 165°C; neat (no solvent);
参考文献
Konstantinova, Igor; Bukhryakov, Konstantin; Gezentsvey, Yuri; Krasavin, Mikhail
Letters in Organic Chemistry, 2011 , vol. 8, # 9 p. 628 - 630
反应条件
T=20 - 165°C; neat (no solvent);
参考文献
Konstantinova, Igor; Bukhryakov, Konstantin; Gezentsvey, Yuri; Krasavin, Mikhail
Letters in Organic Chemistry, 2011 , vol. 8, # 9 p. 628 - 630
反应条件
1: benzyl chloroformate With sodium hydrogencarbonate in water
T=0 - 20°C;
2: bis-(2-chloroethyl)-amine hydrochloride in water
T=0 - 20°C;
参考文献
Lin, Weimin; Gupta, Anuradha; Kim, Kyung Hee; Mendel, David; Miller, Marvin J.
Organic Letters, 2009 , vol. 11, # 2 p. 449 - 452
反应条件
potassium carbonate in butan-1-ol
参考文献
Liu, Kevin G.; Robichaud, Albert J.; Bernotas, Ronald C.; Yan, Yinfa; Lo, Jennifer R.; Zhang, Mei-Yi; Hughes, Zoe A.; Huselton, Christine; Zhang, Guo Ming; Zhang, Jean Y.; Kowal, Dianne M.; Smith, Deborah L.; Schechter, Lee E.; Comery, Thomas A.
Journal of Medicinal Chemistry, 2010 , vol. 53, # 21 p. 7639 - 7646
反应条件
hydrogenchloride; potassium tert-butylate in tetrahydrofuran
16 h; Heating;
参考文献
Nuzzo, Ralph G.; Haynie, Sharon L.; Wilson, Michael E.; Whitesides, George M.
Journal of Organic Chemistry, 1981 , vol. 46, # 14 p. 2861 - 2867
反应条件
(i) aq. NaOH, benzene, (ii) /BRN= 6314981/; Multistep reaction;
参考文献
Khedouri,E. et al.
Journal of Medicinal Chemistry, 1964 , vol. 7, p. 653 - 655
反应条件
in various solvent(s)
30 h; Heating;
参考文献
Romeo, Giuseppe; Materia, Luisa; Manetti, Fabrizio; Cagnotto, Alfredo; Mennini, Tiziana; Nicoletti, Ferdinando; Botta, Maurizio; Russo, Filippo; Minneman, Kenneth P.
Journal of Medicinal Chemistry, 2003 , vol. 46, # 14 p. 2877 - 2894
反应条件
T=20 - 165°C; neat (no solvent);
参考文献
Konstantinova, Igor; Bukhryakov, Konstantin; Gezentsvey, Yuri; Krasavin, Mikhail
Letters in Organic Chemistry, 2011 , vol. 8, # 9 p. 628 - 630
反应条件
sodium hydroxide in ethanol
T=0°C; 2 h;
参考文献
Konrad, Matthias; Meyer, Franc; Heinze, Katja; Zsolnai, Laszlo
Journal of the Chemical Society - Dalton Transactions, 1998 , # 2 p. 199 - 205
