二(2-氯乙基)胺盐酸盐合成路线 （共 164 条）
反应条件
sodium hydroxide in methanol
T=20°C;
参考文献
Spasyuk, Denis; Smith, Samantha; Gusev, Dmitry G.
Angewandte Chemie - International Edition, 2013 , vol. 52, # 9 p. 2538 - 2542
Angew. Chem., 2013 , vol. 125, # 9 p. 2598 - 2602,5
反应条件
1: ethanethiol With sodium hydroxide in ethanol
Inert atmosphere;
2: bis-(2-chloroethyl)-amine hydrochloride in ethanol
T=0 - 20°C; 18 h; Inert atmosphere;
参考文献
Ahmadi, Ebrahim; Mohamadnia, Zahra; Haghighi, Mehdi Nekoomanesh
Catalysis Letters, 2011 , vol. 141, # 8 p. 1191 - 1198
反应条件
triethylamine in dichloromethane
T=15°C; 6 h; Yield given. Yields of byproduct given;
参考文献
Teulade, Marie-Paule; Savignac, Philippe
Phosphorus and Sulfur and the Related Elements, 1984 , vol. 21, p. 23 - 30
反应条件
1: [3,2-c]pyrazole With sodium hydride in N,N-dimethyl-formamide; mineral oil
2 h; Inert atmosphere;
2: bis-(2-chloroethyl)-amine hydrochloride in N,N-dimethyl-formamide; mineral oil
T=60°C; 48 h; Inert atmosphere;
参考文献
Cubanski, John R.; Cameron, Scott A.; Crowley, James D.; Blackman, Allan G.
Dalton Transactions, 2013 , vol. 42, # 6 p. 2174 - 2185
反应条件
NaOD; water-d2
T=37°C; 0.666667 h;
参考文献
Shulman-Roskes, Ellen M.; Noe, Dennis A.; Gamcsik, Michael P.; Marlow, Allison L.; Hilton, John; Hausheer, Frederick H.; Colvin, O. Michael; Ludeman, Susan M.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 4 p. 515 - 529
反应条件
toluene-4-sulfonic acid in chlorobenzene
参考文献
Kuipers, Wilma; Wijngaarden, Ineke van; Kruse, Chris G.; Amstel, Marian ter Horst-van; Tulp, Martin Th. M.; IJzerman, Adriaan P.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 11 p. 1942 - 1954
反应条件
1: With potassium carbonate in diethylene glycol dimethyl ether
T=220°C; 3.5 h; Sealed pressure flask;
2: With sodium hydroxide in dichloromethane; water
pH=9 - 10;
参考文献
ASTRAZENECA AB; NPS PHARMACEUTICALS, INC.
Patent: WO2006/71730 A1, 2006 ;
Location in patent: Page/Page column 80-82 ;
WO 2006/071730 A1
参考文献
Pettit,G.R. et al.
Canadian Journal of Chemistry, 1963 , vol. 41, p. 2962 - 2968
反应条件
sodium hydroxide in anhydrous xylene
参考文献
Juvale, Kapil; Wiese, Michael
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 21 p. 6766 - 6769,4
反应条件
hydrogenchloride; sodium hydroxide; potassium carbonate; potassium hydroxide in ethanol; 2-butoxy-ethanol; water
参考文献
Rhone-Poulenc Sante
Patent: US4547504 A1, 1985 ;
