二(2-氯乙基)胺盐酸盐合成路线 （共 164 条）
反应条件
potassium carbonate in diethylene glycol dimethyl ether
48 h; Heating;
参考文献
Glennon, Richard A.; Slusher, R. M.; Lyon, Robert A.; Titeler, Milt; McKenney, J. D.
Journal of Medicinal Chemistry, 1986 , vol. 29, # 11 p. 2375 - 2380
反应条件
in various solvent(s)
T=150°C;
参考文献
Liu, Kevin G.; Robichaud, Albert J.
Tetrahedron Letters, 2005 , vol. 46, # 46 p. 7921 - 7922
反应条件
potassium carbonate in chlorobenzene
48 h; Heating / reflux;
参考文献
PREDIX PHARMACEUTICALS HOLDINGS, INC.
Patent: WO2004/69794 A2, 2004 ;
Location in patent: Page 62 ;
反应条件
potassium carbonate; potassium iodide
参考文献
Recordati, S.A., Chemical and Pharmacueticals Company
Patent: US6365591 B1, 2002 ;
Location in patent: Example 32 ;
反应条件
pyridine in water
0.25 h;
参考文献
Maysinger; Ban; Movrin
Arzneimittel-Forschung/Drug Research, 1980 , vol. 30, # 6 p. 932 - 935
反应条件
triethylamine; trichlorophosphate in toluene
参考文献
TELIK, INC.
Patent: EP1278759 B1, 2005 ;
反应条件
triethylamine; trichlorophosphate in toluene
T=20°C; 26 h; Heating / reflux;
参考文献
Allen, David R.; Ma, Wenli; Peterson, Brian T.; Robinson, Louise; Schow, Steven R.; Shi, Songyuan; Simon, Reyna J.; Weber, Kevin T.; Wick, Michael M.
Patent: US2005/267075 A1, 2005 ;
Location in patent: Page/Page column 41 ;
反应条件
triethylamine in toluene
16 h; Heating;
参考文献
Borch, Richard F.; Valente, Ronald R.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 10 p. 3052 - 3058
反应条件
triethylamine in toluene
20 h; RefluxLarge scale;
参考文献
Herr, R. Jason; Zhichkin, Paul; Hernandez-Abad, Pedro E.; Meckler, Harold; Schow, Steven R.
Organic Process Research and Development, 2001 , vol. 5, # 4 p. 442 - 444
反应条件
T=20 - 165°C; neat (no solvent);
参考文献
Konstantinova, Igor; Bukhryakov, Konstantin; Gezentsvey, Yuri; Krasavin, Mikhail
Letters in Organic Chemistry, 2011 , vol. 8, # 9 p. 628 - 630
