二(2-氯乙基)胺盐酸盐合成路线 （共 164 条）
反应条件
formic acid T=100 - 120°C; 3.33333 h;
参考文献
Bissantz, Caterina; Grundschober, Christophe; Masciadri, Raffaello; Ratni, Hasane; Rogers-Evans, Mark; Schnider, Patrick
Patent: US2008/161304 A1, 2008 ;
Location in patent: Page/Page column 14 ;
US 20080161304 A1
反应条件
in water T=100°C; 3 h; Reflux;
参考文献
Choi, Jong-Hoo; Schloerer, Nils E.; Berger, Josefine; Prechtl, Martin H. G.
Dalton Transactions, 2014 , vol. 43, # 1 p. 290 - 299
反应条件
potassium carbonate in chlorobenzene T=140°C; 24 h; Inert atmosphere;
参考文献
Arnatt, Christopher K.; Adams, Joanna L.; Zhang, Zhu; Haney, Kendra M.; Li, Guo; Zhang, Yan
Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 10 p. 2319 - 2323
参考文献
Pharmacia and Upjohn Company
Patent: US5877317 A1, 1999 ;
反应条件
1: bis-(2-chloroethyl)-amine hydrochloride With 4-methyl-morpholine; trichlorophosphate in neat (no solvent) T=4 - 20°C; 5 h; Green chemistry; 2: 3-amino-propan-1-ol in neat (no solvent) T=4 - 20°C; 18 h; Green chemistry; Reagent/catalyst;
参考文献
US2014/66654 A1, ;
Paragraph 0039; 0040; 0041; 0042 ;
反应条件
triethylamine in methanol; dichloromethane
反应条件
sodium carbonate 1, 2) n-BuOH, reflux; Yield given. Multistep reaction;
参考文献
Martin; Elgin Jr.; Mathiasen; Davis; Kesslick; Baldy; Shank; DiStefano; Fedde; Scott
Journal of Medicinal Chemistry, 1989 , vol. 32, # 5 p. 1052 - 1056
反应条件
sodium carbonate 1, 2) n-BuOH, reflux; Yield given. Multistep reaction;
参考文献
Martin; Elgin Jr.; Mathiasen; Davis; Kesslick; Baldy; Shank; DiStefano; Fedde; Scott
Journal of Medicinal Chemistry, 1989 , vol. 32, # 5 p. 1052 - 1056
反应条件
formic acid T=75°C; 18 h;
参考文献
Chang, Chih-Shiang; Lin, Ying-Ting; Shih, Shin-Ru; Lee, Chung-Chi; Lee, Yen-Chun; Tai, Chia-Liang; Tseng, Sung-Nien; Chern, Jyh-Haur
Journal of Medicinal Chemistry, 2005 , vol. 48, # 10 p. 3522 - 3535
反应条件
potassium carbonate in butan-1-ol 28 h; Reflux;
参考文献
Qu, Zhibo; Chen, Xiaolan; Qu, Lingbo; Yuan, Jinwei; Li, Huina; Zhao, Yufen
Phosphorus, Sulfur and Silicon and the Related Elements, 2010 , vol. 185, # 7 p. 1516 - 1520
