二(2-氯乙基)胺盐酸盐合成路线 （共 164 条）
反应条件
potassium carbonate in acetonitrile Heating;
参考文献
Chang, Chih-Shiang; Lin, Ying-Ting; Shih, Shin-Ru; Lee, Chung-Chi; Lee, Yen-Chun; Tai, Chia-Liang; Tseng, Sung-Nien; Chern, Jyh-Haur
Journal of Medicinal Chemistry, 2005 , vol. 48, # 10 p. 3522 - 3535
反应条件
(i), (ii) LiAlH4, AlCl3; Multistep reaction;
参考文献
Pettit,G.R. et al.
Canadian Journal of Chemistry, 1963 , vol. 41, p. 2962 - 2968
反应条件
(i), (ii) LiAlH4, AlCl3; Multistep reaction;
参考文献
Pettit,G.R. et al.
Canadian Journal of Chemistry, 1963 , vol. 41, p. 2962 - 2968
反应条件
1: in butan-1-ol 48 h; Heating; 2: With sodium carbonate in butan-1-ol 24 h; Heating;
参考文献
Naito, Hiroyuki; Ohsuki, Satoru; Sugimori, Masamichi; Atsumi, Ryo; Minami, Megumi; Nakamura, Yoshihide; Ishii, Mineko; Hirotani, Kenji; Kumazawa, Eiji; Ejima, Akio
Chemical and pharmaceutical bulletin, 2002 , vol. 50, # 4 p. 453 - 462
反应条件
potassium carbonate in chlorobenzene 30 h; Heating / reflux;
参考文献
XENON PHARMACEUTICALS INC.; ROTH, Carol J.
Patent: WO2006/34441 A1, 2006 ;
Location in patent: Page/Page column 44 ;
WO 2006/034441 A1
反应条件
potassium carbonate in diethyl ether
参考文献
Boehringer Mannheim GmbH
Patent: US4616086 A1, 1986 ;
反应条件
in various solvent(s) T=150°C;
参考文献
Liu, Kevin G.; Robichaud, Albert J.
Tetrahedron Letters, 2005 , vol. 46, # 46 p. 7921 - 7922
参考文献
Soc.Usines Chim.Rhone-Poulenc
Patent: DE818805 , 1951 ;
DRP/DRBP Org.Chem.
参考文献
Hromatka; Kraupp
Monatshefte fuer Chemie, 1951 , vol. 82, p. 880,897
反应条件
in chlorobenzene Reflux;
参考文献
THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL; JIN, Jian; ROTH, Bryan; FRYE, Stephen
Patent: WO2012/3418 A2, 2012 ;
Location in patent: Page/Page column 97 ;
WO 2012/003418 A2
