二(2-氯乙基)胺盐酸盐合成路线 （共 164 条）
反应条件
T=20 - 165°C; neat (no solvent);
参考文献
Konstantinova, Igor; Bukhryakov, Konstantin; Gezentsvey, Yuri; Krasavin, Mikhail
Letters in Organic Chemistry, 2011 , vol. 8, # 9 p. 628 - 630
参考文献
Soc.Usines Chim.Rhone-Poulenc
Patent: DE818805 , 1951 ;
DRP/DRBP Org.Chem.
反应条件
in various solvent(s) T=150°C;
参考文献
Liu, Kevin G.; Robichaud, Albert J.
Tetrahedron Letters, 2005 , vol. 46, # 46 p. 7921 - 7922
反应条件
sodium hydroxide in o-xylene
参考文献
Mitsubishi Pharma Corporation
Patent: US6455528 B1, 2002 ;
反应条件
in ethylene glycol T=130°C; Inert atmosphere;
参考文献
Chemical Communications, , vol. 49, # 89 p. 10474 - 10476
反应条件
hydrogenchloride in 1,4-dioxane T=85 - 95°C; 1 h;
参考文献
Petrosyan, L. M.; Gevorgyan, G. A.; Grigoryan, R. T.; Samvelyan, K. G.; Chachoyan, A. A.; et al.
Pharmaceutical Chemistry Journal, 1985 , vol. 19, # 7 p. 448 - 452
Khimiko-Farmatsevticheskii Zhurnal, 1985 , vol. 19, # 7 p. 800 - 804
反应条件
hydrogenchloride in 1,4-dioxane T=85 - 95°C; 1 h;
参考文献
Petrosyan, L. M.; Gevorgyan, G. A.; Grigoryan, R. T.; Samvelyan, K. G.; Chachoyan, A. A.; et al.
Pharmaceutical Chemistry Journal, 1985 , vol. 19, # 7 p. 448 - 452
Khimiko-Farmatsevticheskii Zhurnal, 1985 , vol. 19, # 7 p. 800 - 804
参考文献
Ishidate,M. et al.
Chemical and Pharmaceutical Bulletin, 1960 , vol. 8, p. 99 - 103
反应条件
hydrogenchloride in 1,4-dioxane T=85 - 95°C; 1 h;
参考文献
Pharmaceutical Chemistry Journal, , vol. 19, # 7 p. 448 - 452
Khimiko-Farmatsevticheskii Zhurnal, , vol. 19, # 7 p. 800 - 804
反应条件
potassium hydroxide in ethanol 16 h;
参考文献
Struck, Robert F.; Kirk, Marion C.; Rice, Louise S.; Suling, William J.
Journal of Medicinal Chemistry, 1986 , vol. 29, # 7 p. 1319 - 1321
