hydrogenchloride; potassium tert-butylate in methanol; sodium hydroxide; dimethyl sulfoxide

potassium tert-butylate in dimethyl sulfoxide T=155°C; 4 h;

1: ZnI2 / CH2Cl2 / 65 h / Ambient temperature 2: 88 percent / HCl / 16 h / 5 °C 3: 57 percent / Et3N / tetrahydrofuran / 1 h / 0 - 5 °C 4: 62 percent / potassium tert-butoxide / dimethylsulfoxide / 4 h / 155 °C View Scheme

1: 88 percent / HCl / 16 h / 5 °C 2: 57 percent / Et3N / tetrahydrofuran / 1 h / 0 - 5 °C 3: 62 percent / potassium tert-butoxide / dimethylsulfoxide / 4 h / 155 °C View Scheme

1: 57 percent / Et3N / tetrahydrofuran / 1 h / 0 - 5 °C 2: 62 percent / potassium tert-butoxide / dimethylsulfoxide / 4 h / 155 °C View Scheme