3-(氯甲基)-3-甲基氧杂环丁烷合成路线 （共 5 条）
反应条件
sodium hydroxide T=70 - 86°C; Yield given;
参考文献
Pharmaceutical Chemistry Journal, , vol. 19, # 2 p. 108 - 111
Khimiko-Farmatsevticheskii Zhurnal, , vol. 19, # 2 p. 161 - 165
反应条件
1: 81 percent / diethyl carbonate, KOH / ethanol / 2 h / Heating 2: 12 percent / triphenylphosphine, pyridine, Cl2 / CHCl3 / 12 h / Ambient temperature View Scheme
参考文献
Acta Chemica Scandinavica, , vol. 45, # 1 p. 82 - 91
反应条件
1: 36 percent / Zn, KI / 10 h / 120 °C 2: 40percent NaOH / 70 - 86 °C View Scheme
参考文献
Pharmaceutical Chemistry Journal, , vol. 19, # 2 p. 108 - 111
Khimiko-Farmatsevticheskii Zhurnal, , vol. 19, # 2 p. 161 - 165
反应条件
sodium iodide in acetone Inert atmosphereReflux;
参考文献
WO2013/156423 A1, ;
Page/Page column 99; 100 ;
反应条件
tetrabutylammomium bromide in water
参考文献
Aerojet-General Corporation
Patent: US5523424 A1, 1996 ;
