1-(5-硝基吡啶-2-基)哌嗪合成路线 （共 10 条）
反应条件
1: With trifluoroacetic acid in dichloromethane T=0 - 20°C; 16 h; 2: With sodium hydroxide in dichloromethane; water
参考文献
Ting, Pauline C.; Lee, Joe F.; Zorn, Nicolas; Kim, Hyunjin M.; Aslanian, Robert G.; Lin, Mingxiang; Smith, Michelle; Walker, Scott S.; Cook, John; Van Heek, Margaret; Lachowicz, Jean
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 4 p. 985 - 988
反应条件
sodium carbonate in 3-methyl-1-butanol 2 h; Heating;
参考文献
Sams, Richard A.; Gerken, Diane F.; Detra, Randall L.; Stanley, Scott D.; Wood, William E.; Tobin, Thomas; Yang, Jyan-Ming; Tai, Hsin-Hsinng; Jegananthan, Alwarsamy; Watt, David S.
Journal of Pharmaceutical Sciences, 1996 , vol. 85, # 1 p. 79 - 84
反应条件
sodium hydroxide; trifluoroacetic acid in dichloromethane
参考文献
Ting, Pauline C.; Aslanian, Robert; Caplen, Mary Ann; Cao, Jianhua; Chan, Tin-Yau; Kim, David; Kim, Hyunjin; Kim, Jae-Hun; Kuang, Rongze; Lee, Joe F.; Schwerdt, John; Wu, Heping; Zorn, Nicolas
Patent: US2011/224137 A1, 2011 ;
US 20110224137 A1
反应条件
potassium carbonate in acetonitrile
反应条件
triethylamine in methanol; acetonitrile T=20°C;
参考文献
Liu, Yu; Liu, Zining; Cao, Xufeng; Liu, Xin; He, Huili; Yang, Yushe
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 16 p. 4779 - 4783
反应条件
1.1: potassium carbonate / water / 0.25 h / 150 °C / Microwave irradiation 2.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C / Inert atmosphere 2.2: 20 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 52, # 45 p. 5905 - 5909
参考文献
Liu, Yu; Liu, Zining; Cao, Xufeng; Liu, Xin; He, Huili; Yang, Yushe
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 16 p. 4779 - 4783
反应条件
1: sodium carbonate 2: palladium 10 on activated carbon; hydrogen / tetrahydrofuran / 20 °C View Scheme
参考文献
Liu, Yu; Liu, Zining; Cao, Xufeng; Liu, Xin; He, Huili; Yang, Yushe
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 16 p. 4779 - 4783
反应条件
palladium 10 on activated carbon; hydrogen in ethanol; ethyl acetate T=70°C; P=750.075 Torr; 0.5 h; H-Cube.(TM).;
参考文献
Spencer, John; Patel, Hiren; Callear, Samantha K.; Coles, Simon J.; Deadman, John J.
Tetrahedron Letters, 2011 , vol. 52, # 45 p. 5905 - 5909
反应条件
1: polymer-supported N-methylmorpholine / dichloromethane / 16 h
2: palladium 10 on activated carbon; hydrogen / ethanol; ethyl acetate / 0.5 h / 70 °C / 750.08 Torr / H-Cube.(TM).
View Scheme
参考文献
Spencer, John; Patel, Hiren; Callear, Samantha K.; Coles, Simon J.; Deadman, John J.
Tetrahedron Letters, 2011 , vol. 52, # 45 p. 5905 - 5909
