4-(2,6-二氯苯基)哌啶合成路线 （共 3 条）
反应条件
1: With dimethylsulfide borane complex in tetrahydrofuran
T=0°C; Inert atmosphereReflux;
2: With hydrogenchloride in tetrahydrofuran; water
T=0°C; Inert atmosphereReflux;
3: With sodium hydroxide in tetrahydrofuran; water
T=0°C;
参考文献
Trapella, Claudio; Fischetti, Carmela; Pela', Michela; Lazzari, Ilaria; Guerrini, Remo; Calo', Girolamo; Rizzi, Anna; Camarda, Valeria; Lambert, David G.; McDonald, John; Regoli, Domenico; Salvadori, Severo
Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 14 p. 5080 - 5095
反应条件
1: in methanol
T=20°C; 1 h;
2: With sodium cyanoborohydride; acetic acid in methanol
36 h;
参考文献
GLAXOSMITHKLINE S.P.A.; CONSONNI, Alessandra
Patent: WO2005/5411 A1, 2005 ;
Location in patent: Page/Page column 62 ;
WO 2005/005411 A1
反应条件
1: 1H-indole-2-carboxylic acid With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in tetrahydrofuran
T=0 - 20°C;
2: 4-(2,6-dichlorophenyl)piperidine in tetrahydrofuran
48 h;
参考文献
GLAXOSMITHKLINE S.P.A.; CONSONNI, Alessandra
Patent: WO2005/5411 A1, 2005 ;
Location in patent: Page/Page column 61 ;
WO 2005/005411 A1
