4-溴-1H-吡唑-1-乙酸乙酯合成路线 （共 2 条）
反应条件
potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct in N,N-dimethyl-formamide T=0 - 80°C;
参考文献
WO2008/88881 A1, ;
Page/Page column 52 ;
WO 2008/088881 A1
反应条件
1: 4-bromo(1H)-pyrazole With sodium hydride in N,N-dimethyl-formamide; mineral oil
T=0°C; 1 h;
2: ethyl bromoacetate With potassium iodide in N,N-dimethyl-formamide; mineral oil
T=0°C; 8 h; Heating;
参考文献
Zhang, Dengyou; Zhang, Xiaowei; Ai, Jing; Zhai, Yun; Liang, Zhongjie; Wang, Ying; Chen, Yi; Li, Chunpu; Zhao, Fei; Jiang, Hualiang; Geng, Meiyu; Luo, Cheng; Liu, Hong
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 21 p. 6804 - 6820
