4-(2-乙氧基-2-氧代亚乙基)哌啶-1-羧酸苄酯合成路线 （共 11 条）
反应条件
hydrogen; palladium on activated charcoal; ethylenediamine in methanol T=20°C; Hydrogenolysis; P=760 Torr; 0.75 h;
参考文献
Tetrahedron, , vol. 56, # 43 p. 8433 - 8441
反应条件
hydrogen; palladium on activated charcoal; ethylenediamine in 1,4-dioxane T=20°C; Hydrogenation; P=760 - 3800 Torr; Product distributionKinetics; Further Variations:SolventsPressures;
参考文献
Hattori, Kazuyuki; Sajiki, Hironao; Hirota, Kosaku
Tetrahedron, 2000 , vol. 56, # 43 p. 8433 - 8441
反应条件
hydrogen; palladium on activated charcoal; ethylenediamine in methanol T=20°C; Hydrogenolysis; P=760 Torr; 0.75 h;
参考文献
Hattori, Kazuyuki; Sajiki, Hironao; Hirota, Kosaku
Tetrahedron, 2000 , vol. 56, # 43 p. 8433 - 8441
反应条件
hydrogen; palladium on activated charcoal; ethylenediamine in 1,4-dioxane T=20°C; Hydrogenation; P=760 - 3800 Torr; Product distributionKinetics; Further Variations:SolventsPressures;
参考文献
Hattori, Kazuyuki; Sajiki, Hironao; Hirota, Kosaku
Tetrahedron, 2000 , vol. 56, # 43 p. 8433 - 8441
反应条件
1: diethoxyphosphoryl-acetic acid ethyl ester With n-butyllithium in tetrahydrofuran; hexanes
T=-78°C; 0.166667 h;
2: 1-benzyloxycarbonyl-piperidin-4-one in tetrahydrofuran; hexanes
T=18 - 25°C; 0.5 h; Product distribution / selectivity;
参考文献
ASTRAZENECA AB
Patent: WO2008/147314 A1, 2008 ;
Location in patent: Page/Page column 63 ;
WO 2008/147314 A1
反应条件
in toluene
18 h; Heating / reflux; Product distribution / selectivity;
参考文献
ASTRAZENECA AB
Patent: WO2008/147314 A1, 2008 ;
Location in patent: Page/Page column 63 ;
WO 2008/147314 A1
反应条件
1: tetrahydrofuran / 20 h / 20 °C
2: 66 percent / PCC/SiO2 / CH2Cl2 / 4 h / 20 °C
3: 74 percent / tetrahydrofuran / 43 h / Heating
View Scheme
参考文献
Hattori, Kazuyuki; Sajiki, Hironao; Hirota, Kosaku
Tetrahedron, 2000 , vol. 56, # 43 p. 8433 - 8441
反应条件
1: tetrahydrofuran / 20 h / 20 °C
2: 66 percent / PCC/SiO2 / CH2Cl2 / 4 h / 20 °C
3: 74 percent / tetrahydrofuran / 43 h / Heating
View Scheme
参考文献
Hattori, Kazuyuki; Sajiki, Hironao; Hirota, Kosaku
Tetrahedron, 2000 , vol. 56, # 43 p. 8433 - 8441
反应条件
1: 66 percent / PCC/SiO2 / CH2Cl2 / 4 h / 20 °C
2: 74 percent / tetrahydrofuran / 43 h / Heating
View Scheme
参考文献
Hattori, Kazuyuki; Sajiki, Hironao; Hirota, Kosaku
Tetrahedron, 2000 , vol. 56, # 43 p. 8433 - 8441
反应条件
1: 96.2 percent / 10percent NaOH / toluene / 2 h
2: 1.) NaH / 1.) abs. Et2O; 2.) abs. Et2O, abs. benzene
View Scheme
参考文献
Takemura; Miki; Kuroda; Ozaki; Suzuki
Chemical and Pharmaceutical Bulletin, 1982 , vol. 30, # 3 p. 1084 - 1087
