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结构式
乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
盐酸托莫西汀
合成路线
（共 26 条）
4850-49-1
1-苯基-1,3-丙二醇
→
反应条件
82248-59-7
盐酸托莫西汀
反应条件
1.1: 95 percent / Et3N / CH2Cl2 / 0 h / -10 °C 2.1: O2; (-)-sparteine; 3 Angstroem sieves / Pd(OAc)2 / toluene / 36 h / 80 °C / 760 Torr 2.2: H2O / tetrahydrofuran / 65 °C 2.3: PPh3; DEAD; HCl (g) / diethyl ether / -10 - 0 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 43, # 31 p. 5435 - 5436
73627-97-1
→
反应条件
82248-59-7
盐酸托莫西汀
反应条件
1: hydrogen, NH3 / Raney Ni / ethanol / 90 °C / p(NH3) = 30 psi and p(H2) = 170 psi 2: NaHCO3 / tetrahydrofuran 3: LiAlH4 / tetrahydrofuran / Heating 4: 1) DEAD, Ph3P View Scheme
参考文献
Tetrahedron Letters, , vol. 35, # 9 p. 1339 - 1342
114133-37-8
(S)-3-(甲基氨基)-1-苯丙醇
→
反应条件
82248-59-7
盐酸托莫西汀
反应条件
1: 95 percent / CH2Cl2 / 2 h / Heating 2: 84.4 percent / PPh3, diethyl azodicarboxylate / diethyl ether / 5 h / -10 °C 3: 88.7 percent / HCl gas / ethanol / Ambient temperature View Scheme
参考文献
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, , vol. 31, # 12 p. 803 - 809
76183-10-3
→
反应条件
82248-59-7
盐酸托莫西汀
反应条件
1: 97.6 percent / LiAlH4 / tetrahydrofuran / 2 h / Heating 2: 95 percent / CH2Cl2 / 2 h / Heating 3: 84.4 percent / PPh3, diethyl azodicarboxylate / diethyl ether / 5 h / -10 °C 4: 88.7 percent / HCl gas / ethanol / Ambient temperature View Scheme
参考文献
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, , vol. 31, # 12 p. 803 - 809
134619-77-5
→
反应条件
82248-59-7
盐酸托莫西汀
反应条件
1: 84.4 percent / PPh3, diethyl azodicarboxylate / diethyl ether / 5 h / -10 °C 2: 88.7 percent / HCl gas / ethanol / Ambient temperature View Scheme
参考文献
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, , vol. 31, # 12 p. 803 - 809
100306-34-1
(S)-(-)-3-氯-1-苯基-1-丙醇
→
反应条件
82248-59-7
盐酸托莫西汀
反应条件
1: 70 percent / triphenylphosphine, diethyl azodicarboxylate / tetrahydrofuran / Ambient temperature 2: 95 percent / ethanol; H2O / 3 h / 130 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 53, # 13 p. 2916 - 2920
95-48-7
邻甲酚
→
反应条件
82248-59-7
盐酸托莫西汀
反应条件
1: 70 percent / triphenylphosphine, diethyl azodicarboxylate / tetrahydrofuran / Ambient temperature 2: 95 percent / ethanol; H2O / 3 h / 130 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 53, # 13 p. 2916 - 2920
118856-08-9
→
反应条件
82248-59-7
盐酸托莫西汀
反应条件
1.1: Candida rugosa lipase; MgCl2 / H2O; diisopropyl ether / 24 h / 30 °C 2.1: 95 percent / LiAlH4 / tetrahydrofuran / 1 h / 20 °C 3.1: 85 percent / Et3N / diethyl ether / 3 h / -10 - 0 °C / cooling 4.1: DEAD; PPh3 / diethyl ether; toluene / 30 h / -10 °C 4.2: 78 percent / diethyl ether; toluene / 2.5 h / -10 °C 5.1: 82 percent / H2O; tetrahydrofuran / 4 h / 60 - 65 °C 6.1: 99 percent / HCl / diethyl ether View Scheme
参考文献
Tetrahedron, , vol. 61, # 8 p. 2169 - 2186
838841-85-3
→
反应条件
82248-59-7
盐酸托莫西汀
反应条件
1.1: 95 percent / LiAlH4 / tetrahydrofuran / 1 h / 20 °C 2.1: 85 percent / Et3N / diethyl ether / 3 h / -10 - 0 °C / cooling 3.1: DEAD; PPh3 / diethyl ether; toluene / 30 h / -10 °C 3.2: 78 percent / diethyl ether; toluene / 2.5 h / -10 °C 4.1: 82 percent / H2O; tetrahydrofuran / 4 h / 60 - 65 °C 5.1: 99 percent / HCl / diethyl ether View Scheme
参考文献
Tetrahedron, , vol. 61, # 8 p. 2169 - 2186
96854-34-1
(S)-1-苯基-1,3-丙二醇
→
反应条件
82248-59-7
盐酸托莫西汀
反应条件
1.1: 85 percent / Et3N / diethyl ether / 3 h / -10 - 0 °C / cooling 2.1: DEAD; PPh3 / diethyl ether; toluene / 30 h / -10 °C 2.2: 78 percent / diethyl ether; toluene / 2.5 h / -10 °C 3.1: 82 percent / H2O; tetrahydrofuran / 4 h / 60 - 65 °C 4.1: 99 percent / HCl / diethyl ether View Scheme
参考文献
Tetrahedron, , vol. 61, # 8 p. 2169 - 2186
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