4-甲氧基-3-吡啶甲醛合成路线 （共 16 条）
反应条件
2-Bromo-1,3,5-trimethyl-benzene; tert.-butyl lithium
参考文献
Tetrahedron Letters, , vol. 47, # 1 p. 39 - 41
反应条件
1: 2-Bromo-1,3,5-trimethyl-benzene; tert.-butyl lithium in tetrahydrofuran T=-78°C; 1 h; 2: 4-methoxy pyridine; N,N-dimethyl-formamide in tetrahydrofuran; pentane T=-78 - 23°C; 4 h;
参考文献
WO2004/41806 A2, ;
Page 65 ;
WO 2004/041806 A2
反应条件
1: bromo-3 methoxy-4 pyridine With n-butyllithium in tetrahydrofuran T=-78°C; 2: N,N-dimethyl-formamide in tetrahydrofuran Further stages.;
参考文献
European Journal of Organic Chemistry, , # 13 p. 2126 - 2135
反应条件
in tetrahydrofuran; hexane T=-35°C; 1.5 h;
参考文献
WO2004/92125 A2, ;
Page 7 ;
反应条件
in methanol 0.5 h; Heating;
参考文献
Journal of Heterocyclic Chemistry, , vol. 25, p. 81 - 87
反应条件
1: catalyst: Pd/C (5percent), H2 / methanol 2: 1.) mesityllithium / 1.) -23 deg C, 3 h View Scheme
参考文献
Tetrahedron Letters, , vol. 29, # 7 p. 773 - 776
反应条件
1: 1) LDA / 1) -70 deg C, 4 h, 2) THF, -70 deg C, 3 h 2: 90 percent / methanol / 0.5 h / Heating View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 25, p. 81 - 87
反应条件
1: 61 percent / Na / ethanol / 72 h / -15 °C 2: 67 percent / o-xylene / 0.42 h / 170 °C 3: 93 percent / LiAlH4 / tetrahydrofuran / 0.5 h / Heating View Scheme
参考文献
Fresneda, Pilar M.; Molina, Pedro; Delgado, Santiago; Bleda, Juan A.
Tetrahedron Letters, 2000 , vol. 41, # 24 p. 4777 - 4780
反应条件
1: 61 percent / Na / ethanol / 72 h / -15 °C 2: 67 percent / o-xylene / 0.42 h / 170 °C View Scheme
参考文献
Fresneda, Pilar M.; Molina, Pedro; Delgado, Santiago; Bleda, Juan A.
Tetrahedron Letters, 2000 , vol. 41, # 24 p. 4777 - 4780
反应条件
1: 61 percent / Na / ethanol / 72 h / -15 °C 2: 67 percent / o-xylene / 0.42 h / 170 °C 3: 94 percent / sodium hydride / dimethylformamide / 12 h / 20 °C View Scheme
参考文献
Fresneda, Pilar M.; Molina, Pedro; Delgado, Santiago; Bleda, Juan A.
Tetrahedron Letters, 2000 , vol. 41, # 24 p. 4777 - 4780
