4-甲氧基-3-吡啶甲醛合成路线 （共 16 条）
反应条件
1: With hydroxylamine hydrochloride in methanol T=25°C; 4 h; 2: With pyridine; methanesulfonyl chloride T=25°C; 2 h;
参考文献
French, Jarrod B.; Cen, Yana; Vrablik, Tracy L.; Xu, Ping; Allen, Eleanor; Hanna-Rose, Wendy; Sauve, Anthony A.
Biochemistry, 2010 , vol. 49, # 49 p. 10421 - 10439
反应条件
1: 61 percent / Na / ethanol / 72 h / -15 °C 2: 67 percent / o-xylene / 0.42 h / 170 °C 3: 93 percent / LiAlH4 / tetrahydrofuran / 0.5 h / Heating 4: 60 percent / MnO2 / CH2Cl2 / 72 h / 20 °C View Scheme
参考文献
Fresneda, Pilar M.; Molina, Pedro; Delgado, Santiago; Bleda, Juan A.
Tetrahedron Letters, 2000 , vol. 41, # 24 p. 4777 - 4780
反应条件
1: triphenylphosphine / dichloromethane / 1 h / 0 °C 2: n-butyllithium / tetrahydrofuran; pentane / 1 h / -78 °C View Scheme
参考文献
NOVARTIS AG
Patent: WO2009/156462 A2, 2009 ;
反应条件
Yield given. Multistep reaction;
参考文献
Comins, Daniel L.; Killpack, Michael O.
Journal of Organic Chemistry, 1990 , vol. 55, # 1 p. 69 - 73
反应条件
1.1: hydroxylamine hydrochloride / methanol / 4 h / 25 °C
1.2: 2 h / 25 °C
2.1: dihydrogen peroxide; potassium carbonate / dimethyl sulfoxide / 1 h
View Scheme
参考文献
French, Jarrod B.; Cen, Yana; Vrablik, Tracy L.; Xu, Ping; Allen, Eleanor; Hanna-Rose, Wendy; Sauve, Anthony A.
Biochemistry, 2010 , vol. 49, # 49 p. 10421 - 10439
反应条件
1: in dichloromethane
T=20°C; 1 h;
2: With sodium tris(acetoxy)borohydride in dichloromethane
T=0 - 20°C; 3 h;
3: With hydrogenchloride; sodium hydroxide
Product distribution / selectivity; more than 3 stages;
参考文献
THERAVANCE, INC.
Patent: WO2005/42514 A2, 2005 ;
Location in patent: Page/Page column 30 ;
WO 2005/042514 A2
