1: 2-Mercapto-pyrimidine With sodium hydride in tetrahydrofuran T=0°C; 0.5 h; 2: methyl iodide in tetrahydrofuran T=20°C; 4 h;

tetrabutylammomium bromide; potassium carbonate T=90°C; P=760.051 Torr; 2.5 h;

in 1-methyl-pyrrolidin-2-one T=70°C; 0.00972222 h; microwave irradiation;

in 1-methyl-pyrrolidin-2-one T=95°C; 0.0138889 h; microwave irradiation;

potassium carbonate in water; acetone 20 h;

Bu3SnLi in tetrahydrofuran

n-butyllithium in tetrahydrofuran; hexane Addn. of butyl-lithium in hexane to a stirred soln. of CH3SC4H2N2Br in THF under N2 at -95°C followed by stirring for 60 min at -85°C, addn. of (CH3)3SnCl at -90°C, stirring for 30 min at -85°C and 20 h at 0°C.; Pouring into aq. ammonium chloride, stirring 10 min, sepn. of two phases, extn. of aq. phase with chloroform, washing the org. phases, drying (MgSO4), evapn., flash chromy. (silica gel; light petroleum-EtOAc), elem. anal.;

1: 2-pyrimidinyl chloride With potassium tert-butylate; thiourea in dimethyl sulfoxide 3 h; UV-irradiation; 2: methyl iodide in water; dimethyl sulfoxide

sodium hydrogencarbonate

ammonium hydroxide; sodium chloride; zinc