4-氟苯肼盐酸盐合成路线

71987-67-2(5-氟-2-甲基-1H-吲哚-3-基)乙酸

参考文献

Menciu, Cecilia; Duflos, Muriel; Fouchard, Fabienne; Le Baut, Guillaume; Emig, Peter; Achterrath, Ute; Szelenyi, Istvan; Nickel, Bernd; Schmidt, Juergen; Kutscher, Bernhard; Guenther, Eckhardt
Journal of Medicinal Chemistry, 1999 , vol. 42, # 4 p. 638 - 648

823-85-84-氟苯肼盐酸盐+

123-76-2乙酰丙酸

71987-67-2(5-氟-2-甲基-1H-吲哚-3-基)乙酸

参考文献

Iwahashi, Maki; Shimabukuro, Atsushi; Onoda, Takahiro; Matsunaga, Yoko; Okada, Yutaka; Matsumoto, Ryoji; Nambu, Fumio; Nakai, Hisao; Toda, Masaaki
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 15 p. 4574 - 4588

823-85-84-氟苯肼盐酸盐+

78-93-3丁酮

526-47-62,3-二甲基-5-氟吲哚

参考文献

Lopez-Iglesias, Maria; Busto, Eduardo; Gotor, Vicente; Gotor-Fernandez, Vicente
Journal of Organic Chemistry, 2012 , vol. 77, # 18 p. 8049 - 8055,7
Title/Abstract Full Text Show Details
Lopez-Iglesias, Maria; Busto, Eduardo; Gotor, Vicente; Gotor-Fernandez, Vicente
Journal of Organic Chemistry, 2012 , vol. 77, # 18 p. 8049 - 8055

823-85-84-氟苯肼盐酸盐+

141-97-9乙酰乙酸乙酯

100553-83-11-(4-氟苯基)-3-甲基-2-吡唑啉-5-酮

参考文献

Tagawa, Yoshinobu; Minami, Shin'ichi; Yoshida, Toshio; Tanaka, Keitaro; Sato, Shuji; Goto, Yoshinobu; Yamagata, Kenji
Archiv der Pharmazie (Weinheim, Germany), 2002 , vol. 335, # 2 p. 99 - 103

17159-79-4对环己酮甲酸乙酯+

823-85-84-氟苯肼盐酸盐

322725-63-36-氟-2,3,4,9-四氢-1H-咔唑-3-羧酸乙酯

参考文献

Nikitenko, Antonia; Evrard, Deborah; Sabb, Annmarie L.; Vogel, Robert L.; Stack, Gary; Young, Mairead; Lin, Melissa; Harrison, Boyd L.; Potoski, John R.
Organic Process Research and Development, 2008 , vol. 12, # 1 p. 76 - 80

823-85-84-氟苯肼盐酸盐

3296-02-41-叠氮基-4-氟苯

参考文献

BANYU PHARMACEUTICAL CO., LTD.
Patent: EP1764362 A1, 2007 ;
Location in patent: Page/Page column 39 ;

823-85-84-氟苯肼盐酸盐+

94-05-32-氰基-3-乙氧基丙烯酸乙酯

138907-68-35-氨基-1-(4-氟苯)吡唑-4-羧酸乙酯

参考文献

CHROMA THERAPEUTICS LTD.
Patent: WO2008/53136 A1, 2008 ;
Location in patent: Page/Page column 35-36 ;
WO 2008/053136 A1

42466-67-1(E)-2-氰基-3-乙氧基丙烯酸乙酯+

823-85-84-氟苯肼盐酸盐

138907-68-35-氨基-1-(4-氟苯)吡唑-4-羧酸乙酯

参考文献

Sutherland, Hamish S.; Blaser, Adrian; Kmentova, Iveta; Franzblau, Scott G.; Wan, Baojie; Wang, Yuehong; Ma, Zhenkun; Palmer, Brian D.; Denny, William A.; Thompson, Andrew M.
Journal of Medicinal Chemistry, 2010 , vol. 53, # 2 p. 855 - 866

823-85-84-氟苯肼盐酸盐+

123-76-2乙酰丙酸

17536-39-95-氟-2-甲基-3-吲哚乙酸乙酯

参考文献

American Cyanamid Company
Patent: US4302589 A1, 1981 ;

823-85-84-氟苯肼盐酸盐+

539-88-8乙酰丙酸乙酯

17536-39-95-氟-2-甲基-3-吲哚乙酸乙酯

参考文献

Armer, Richard E.; Ashton, Mark R.; Boyd, Edward A.; Brennan, Chris J.; Brookfield, Frederick A.; Gazi, Lucien; Gyles, Shan L.; Hay, Philip A.; Hunter, Michael G.; Middlemiss, David; Whittaker, Mark; Xue, Luzheng; Pettipher, Roy
Journal of Medicinal Chemistry, 2005 , vol. 48, # 20 p. 6174 - 6177