1: 2-chloro-6-methoxy-3-nitro-pyridine With tetrakis(triphenylphosphine) palladium(0) in 1,4-dioxane; water 0.25 h; 2: trimethylboroxine With potassium carbonate in 1,4-dioxane; water T=20°C; 22 h; Heating / reflux;
参考文献
OSI PHARMACEUTICALS, INC.
Patent: WO2004/104001 A2, 2004 ;
Location in patent: Page 43 ;
WO 2004/104001 A2