sodium hydroxide in methanol 1.) 25 deg C, 18 h, 2.) reflux, 1 h;

1: NaHCO3 / toluene; ethanol / 16 h / Heating 2: 52 percent / N,N-dimethyl-acetamide / 1.) 25 deg C, 18 h, 2.) 60 deg C, 6 h, 3.) 80 deg C, 1 h 3: 81 percent / 1N aq. NaOH / methanol / 1.) 25 deg C, 18 h, 2.) reflux, 1 h View Scheme

1: 52 percent / N,N-dimethyl-acetamide / 1.) 25 deg C, 18 h, 2.) 60 deg C, 6 h, 3.) 80 deg C, 1 h 2: 81 percent / 1N aq. NaOH / methanol / 1.) 25 deg C, 18 h, 2.) reflux, 1 h View Scheme