反应条件
1: 55 percent / 2,2,6,6-tetramethylpiperidine; n-BuLi
2: 63 percent / Pd2(dba)3; BINAP; t-BuONa
3: 83 percent / aq. HCl / tetrahydrofuran / 20 °C
4: 100 percent / dioxane
5: NH2OH*HCl; pyridine / ethanol
6: NaOH / ethanol
View Scheme
参考文献
Zhang, Deyi; Kohlman, Dan; Krushinski, Joseph; Liang, Sidney; Ying, Bai-Ping; Reilly, John E.; Dinn, Sean R.; Wainscott, David B.; Nutter, Suzanne; Gough, Wendy; Nelson, David L.G.; Schaus, John M.; Xu, Yao-Chang
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 24 p. 6011 - 6016