(5Z,8Z,10E,12R,14Z)-12-羟基-5,8,10,14-二十碳四烯酸合成路线 （共 25 条）
反应条件
1: 1.) H5IO6; 2.) CaSO4 / 1.) THF, 0 deg C, 5 min
3: 1.) NaOH / 1.) MeOH/H2O; 2.) pH 4
View Scheme
参考文献
Manna; Viala; Yadagiri; Falck
Tetrahedron Letters, 1986 , vol. 27, # 24 p. 2679 - 2682
反应条件
1: 1.) NaN(TMS)2 / 1.) THF, 0 deg C to 25 deg C
View Scheme
参考文献
Taffer, Ira M.; Zipkin, Robert E.
Tetrahedron Letters, 1987 , vol. 28, # 52 p. 6543 - 6544
反应条件
1: 1.) NaN(TMS)2 / 1.) THF, 0 deg C to 25 deg C
View Scheme
参考文献
Taffer, Ira M.; Zipkin, Robert E.
Tetrahedron Letters, 1987 , vol. 28, # 52 p. 6543 - 6544
反应条件
1: With Physcomitrella patens lipoxygenase PpLOX7; oxygen
pH=7.0; 0.5 h; aq. phosphate bufferEnzymatic reaction;
2: With sodium tetrahydroborate in methanol
0.5 h; enantiospecific reaction;
参考文献
Anterola, Aldwin; Goebel, Cornelia; Hornung, Ellen; Sellhorn, George; Feussner, Ivo; Grimes, Howard
Phytochemistry, 2009 , vol. 70, # 1 p. 45 - 57
反应条件
Yield given. Multistep reaction;
参考文献
Taffer, Ira M.; Zipkin, Robert E.
Tetrahedron Letters, 1987 , vol. 28, # 52 p. 6543 - 6544
