N-乙酰基-DL-(3-三氟甲基)苯丙氨酸合成路线 （共 6 条）
反应条件
1: 86 percent / BF3*OEt2 / 1 h / Heating 3: 95 percent / 6N aq. HCl / 2 h / Heating 4: 91 percent / 1N aq. NaOH, MgO / dioxane / 25 °C View Scheme
参考文献
Nestor Jr.; Ho; Simpson; Horner; Jones; McRae; Vickery
Journal of Medicinal Chemistry, 1982 , vol. 25, # 7 p. 795 - 801
参考文献
Filler,R.; Novar,H.
Journal of Organic Chemistry, 1960 , vol. 25, p. 733 - 736
反应条件
hydrogen; palladium on activated charcoal
参考文献
Filler,R.; Novar,H.
Journal of Organic Chemistry, 1960 , vol. 25, p. 733 - 736
反应条件
1: (hydrolysis)
2: H2 / Pd-C
View Scheme
参考文献
Filler,R.; Novar,H.
Journal of Organic Chemistry, 1960 , vol. 25, p. 733 - 736
参考文献
Nestor Jr.; Ho; Simpson; Horner; Jones; McRae; Vickery
Journal of Medicinal Chemistry, 1982 , vol. 25, # 7 p. 795 - 801
反应条件
1: 86 percent / BF3*OEt2 / 1 h / Heating
3: 95 percent / 6N aq. HCl / 2 h / Heating
View Scheme
参考文献
Nestor Jr.; Ho; Simpson; Horner; Jones; McRae; Vickery
Journal of Medicinal Chemistry, 1982 , vol. 25, # 7 p. 795 - 801
