4-(2-氧代哌啶-1-基)丁酸合成路线 （共 7 条）
反应条件
potassium hydroxide in ethanol
16 h; Ambient temperature;
参考文献
McIntosh, John M.
Tetrahedron, 1982 , vol. 38, # 2 p. 261 - 266
反应条件
sodium hydroxide; silver nitrate
T=0°C; 0.0833333 h;
参考文献
Dado; Gellman
Journal of the American Chemical Society, 1994 , vol. 116, # 3 p. 1054 - 1062
反应条件
1: 77 percent / Amberlyst-15 / methanol / 6 h / 45 °C
2: 1.) (COCl)2, DMSO, 2.) Et3N / 1.) CH2Cl2, -60 deg C, 15 min, 2.) CH2Cl2, -60 deg C, 5 min
3: AgNO3, aq. NaOH / 0.08 h / 0 °C
View Scheme
参考文献
Dado; Gellman
Journal of the American Chemical Society, 1994 , vol. 116, # 3 p. 1054 - 1062
反应条件
1: 100 percent / H2 / PtO2 / ethanol / 5 h / 2052 Torr
2: 86 percent / KOH aq. / ethanol / 16 h / Ambient temperature
View Scheme
参考文献
McIntosh, John M.
Tetrahedron, 1982 , vol. 38, # 2 p. 261 - 266
反应条件
1: 1.) (COCl)2, DMSO, 2.) Et3N / 1.) CH2Cl2, -60 deg C, 15 min, 2.) CH2Cl2, -60 deg C, 5 min
2: AgNO3, aq. NaOH / 0.08 h / 0 °C
View Scheme
参考文献
Dado; Gellman
Journal of the American Chemical Society, 1994 , vol. 116, # 3 p. 1054 - 1062
反应条件
sodium
1) 90-120 deg C, 2) 120-130 deg C; Yield given. Multistep reaction;
参考文献
Miyano, Seiji; Fujii, Shinichiro; Yamashita, Osamu; Toraishi, Naoko; Sumoto, Kunihiro
Journal of Heterocyclic Chemistry, 1982 , vol. 19, p. 1465 - 1468
参考文献
McHintosh, John M.; Pillon, Lilianna Z.; Acquaah, Samuel O.; Green, James R.; White, Graham S.
Canadian Journal of Chemistry, 1983 , vol. 61, p. 2016 - 2021
