BOC-MET-ENKEPHALIN-T-BUTYL ESTER合成路线 （共 11 条）
反应条件
methyl-phenyl-thioether; trifluoroacetic acid 1 h; Ambient temperature;
参考文献
Okada; Ohta
Chemical and Pharmaceutical Bulletin, 1982 , vol. 30, # 2 p. 581 - 585
反应条件
in N,N-dimethyl-formamide
T=4°C;
参考文献
Okada; Ohta
Chemical and Pharmaceutical Bulletin, 1982 , vol. 30, # 2 p. 581 - 585
反应条件
1: 45 percent / DCC / acetonitrile / -10 °C
2: palladium / ethanol; cyclohexene / 0.5 h / Heating
3: 59 percent / DCC, 1-hydroxybenzotriazole / acetonitrile; dimethylformamide / -10 °C
4: palladium / ethanol / 0.5 h / Heating
5: 46 percent / dimethylformamide / 4 °C
View Scheme
参考文献
Okada; Ohta
Chemical and Pharmaceutical Bulletin, 1982 , vol. 30, # 2 p. 581 - 585
反应条件
1: 45 percent / DCC / acetonitrile / -10 °C
2: palladium / ethanol; cyclohexene / 0.5 h / Heating
3: 59 percent / DCC, 1-hydroxybenzotriazole / acetonitrile; dimethylformamide / -10 °C
4: palladium / ethanol / 0.5 h / Heating
5: 46 percent / dimethylformamide / 4 °C
View Scheme
参考文献
Okada; Ohta
Chemical and Pharmaceutical Bulletin, 1982 , vol. 30, # 2 p. 581 - 585
反应条件
1: palladium black / ethanol; cyclohexene / 3 h / Heating
2: 45 percent / DCC / acetonitrile / -10 °C
3: palladium / ethanol; cyclohexene / 0.5 h / Heating
4: 59 percent / DCC, 1-hydroxybenzotriazole / acetonitrile; dimethylformamide / -10 °C
5: palladium / ethanol / 0.5 h / Heating
6: 46 percent / dimethylformamide / 4 °C
View Scheme
参考文献
Okada; Ohta
Chemical and Pharmaceutical Bulletin, 1982 , vol. 30, # 2 p. 581 - 585
反应条件
1: 59 percent / DCC, 1-hydroxybenzotriazole / acetonitrile; dimethylformamide / -10 °C
2: palladium / ethanol / 0.5 h / Heating
3: 46 percent / dimethylformamide / 4 °C
View Scheme
参考文献
Okada; Ohta
Chemical and Pharmaceutical Bulletin, 1982 , vol. 30, # 2 p. 581 - 585
反应条件
1: palladium / ethanol; cyclohexene / 0.5 h / Heating
2: 59 percent / DCC, 1-hydroxybenzotriazole / acetonitrile; dimethylformamide / -10 °C
3: palladium / ethanol / 0.5 h / Heating
4: 46 percent / dimethylformamide / 4 °C
View Scheme
参考文献
Okada; Ohta
Chemical and Pharmaceutical Bulletin, 1982 , vol. 30, # 2 p. 581 - 585
反应条件
1: 60 percent / DCC / acetonitrile / -10 °C
2: 36 percent / hydrazine hydrate / methanol / Ambient temperature
3: isopentyl nitrite
4: 46 percent / dimethylformamide / 4 °C
View Scheme
参考文献
Okada; Ohta
Chemical and Pharmaceutical Bulletin, 1982 , vol. 30, # 2 p. 581 - 585
反应条件
1: 36 percent / hydrazine hydrate / methanol / Ambient temperature
2: isopentyl nitrite
3: 46 percent / dimethylformamide / 4 °C
View Scheme
参考文献
Okada; Ohta
Chemical and Pharmaceutical Bulletin, 1982 , vol. 30, # 2 p. 581 - 585
反应条件
1: isopentyl nitrite
2: 46 percent / dimethylformamide / 4 °C
View Scheme
参考文献
Okada; Ohta
Chemical and Pharmaceutical Bulletin, 1982 , vol. 30, # 2 p. 581 - 585
