6-甲基-7-氮杂-吲哚合成路线 （共 18 条）
反应条件
dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct; potassium carbonate in ethylene glycol dimethyl ether T=120°C; 2 h; Microwave irradiation;
参考文献
Almirall, S.A.; Vidal Juan, Bernat; Alonso Diez, Juan Antonio; Buil Albero, María Antonia; Eastwood, Paul Robert; Esteve Trias, Cristina; Lozoya Toribio, María Estrella; Roberts, Richard Spurring; Vidal Gispert, Laura
Patent: EP2548876 A1, 2013 ;
Location in patent: Paragraph 0442-0445 ;
EP 2548876 A1
反应条件
sodium hydroxide in ethanol; water 8 h; Heating / reflux;
参考文献
Tung, Yen-Shih; Coumar, Mohane Selvaraj; Wu, Yu-Shan; Shiao, Hui-Yi; Chang, Jang-Yang; Liou, Jing-Ping; Shukla, Paritosh; Chang, Chun-Wei; Chang, Chi-Yen; Kuo, Ching-Chuan; Yeh, Teng-Kuang; Lin, Chin-Yu; Wu, Jian-Sung; Wu, Su-Ying; Liao, Chun-Chen; Hsieh, Hsing-Pang
Journal of Medicinal Chemistry, 2011 , vol. 54, # 8 p. 3076 - 3080
反应条件
water; sodium hydroxide in ethanol 8 h; Reflux;
参考文献
The University of Tokyo; Riken; NAGANO Tetsuo; OKABE Takayoshi; KOJIMA Hirotatsu; SAITO Nae; NAKANO Hirofumi; ABE Masanao; TANAKA Akiko; HONMA Teruki; YOKOYAMA Shigeyuki; TSUGANEZAWA Keiko; YUKI Hitomi
Patent: EP2565192 A1, 2013 ;
Location in patent: Paragraph 0289 ;
反应条件
hydrogenchloride in diethyl ether; water; pentane T=-20°C; Inert atmosphereReflux;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 19, # 7 p. 2006 - 2008
反应条件
1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / Inert atmosphere 2: water; sodium hydroxide / tetrahydrofuran / 16 h / 20 °C / Inert atmosphere 3: sodium hydroxide / dichloromethane / 8 h / 20 °C / Inert atmosphere 4: tetrakis(triphenylphosphine) palladium(0) / tetrahydrofuran / 40 h / Inert atmosphere; Reflux 5: sodium hydroxide / ethanol; water / 8 h / Reflux; Inert atmosphere View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 54, # 8 p. 3076 - 3080
反应条件
1: 87 percent / PCl5 / CHCl3 / 3 h / Heating 2: NaH, N-methylaniline / Heating View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 33, # 2 p. 303 - 308
反应条件
1: 3-chloro-benzenecarboperoxoic acid / ethyl acetate / 2 h / 20 °C 2: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / Inert atmosphere 3: water; sodium hydroxide / tetrahydrofuran / 16 h / 20 °C / Inert atmosphere 4: sodium hydroxide / dichloromethane / 8 h / 20 °C / Inert atmosphere 5: tetrakis(triphenylphosphine) palladium(0) / tetrahydrofuran / 40 h / Inert atmosphere; Reflux 6: sodium hydroxide / ethanol; water / 8 h / Reflux; Inert atmosphere View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 54, # 8 p. 3076 - 3080
反应条件
1: water; sodium hydroxide / tetrahydrofuran / 16 h / 20 °C / Inert atmosphere 2: sodium hydroxide / dichloromethane / 8 h / 20 °C / Inert atmosphere 3: tetrakis(triphenylphosphine) palladium(0) / tetrahydrofuran / 40 h / Inert atmosphere; Reflux 4: sodium hydroxide / ethanol; water / 8 h / Reflux; Inert atmosphere View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 54, # 8 p. 3076 - 3080
反应条件
1: sodium hydroxide / dichloromethane / 8 h / 20 °C / Inert atmosphere 2: tetrakis(triphenylphosphine) palladium(0) / tetrahydrofuran / 40 h / Inert atmosphere; Reflux 3: sodium hydroxide / ethanol; water / 8 h / Reflux; Inert atmosphere View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 54, # 8 p. 3076 - 3080
反应条件
1: sodium hydroxide; methanol / 4 h / 20 °C 2: potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct / ethylene glycol dimethyl ether / 2 h / 120 °C / |Microwave irradiation View Scheme
