Drake, Christopher R.; Aissaoui, Abderrahim; Argyros, Orestis; Serginson, James M.; Monnery, Bryn D.; Thanou, Maya; Steinke, Joachim H. G.; Miller, Andrew D.
Molecular Pharmaceutics, 2010 , vol. 7, # 6 p. 2040 - 2055
1: 1-chloro-4-bromobenzene With potassium hydroxide; tris-(dibenzylideneacetone)dipalladium(0); di-tert-butyl(2′,4′,6′-triisopropylbiphenyl-2-yl)phosphine in 1,4-dioxane; water T=100°C; 1 h; 2: p-methoxybenzyl chloride With N-hexadecyl-N,N,N-trimethylammonium bromide in 1,4-dioxane; water T=100°C; 1 h;
参考文献
Anderson, Kevin W.; Ikawa, Takashi; Tundel, Rachel E.; Buchwald, Stephen L.
Journal of the American Chemical Society, 2006 , vol. 128, # 33 p. 10694 - 10695
1: mercaptoacetic acid With sodium hydroxide in methanol T=0°C; 0.5 h; 2: p-methoxybenzyl chloride in methanol 2 h; Heating / reflux;
参考文献
TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION; ONCONOVA THERAPEUTICS INC.
Patent: WO2005/46599 A2, 2005 ;
Location in patent: Page/Page column 87; 88 ;
1: benzyl alcohol With sodium hydride in N,N-dimethyl-formamide; mineral oil T=0°C; 0.5 h; 2: p-methoxybenzyl chloride in N,N-dimethyl-formamide; mineral oil T=0 - 20°C;
