反应条件
1.1: 50 percent / K2CO3; Bu4NCl / dimethylformamide / 84 h / 20 °C
2.1: Pd2(dba)3; BINAP; tBuONa / toluene / 3 h / 80 °C
3.1: aq. HCl / tetrahydrofuran / 0.25 h / 20 °C
4.1: 55 percent / KN(TMS)2 / tetrahydrofuran / 20 °C
5.1: nBuLi / tetrahydrofuran / -78 °C
5.2: 65 percent / tetrahydrofuran / 0.75 h / -78 - 10 °C
View Scheme
参考文献
Li, Qun; Woods, Keith W.; Thomas, Sheela; Zhu, Gui-Dong; Packard, Garrick; Fisher, John; Li, Tongmei; Gong, Jianchun; Dinges, Jurgen; Song, Xiaohong; Abrams, Jason; Luo, Yan; Johnson, Eric F.; Shi, Yan; Liu, Xuesong; Klinghofer, Vered; Des Jong, Ron; Oltersdorf, Tilman; Stoll, Vincent S.; Jakob, Clarissa G.; Rosenberg, Saul H.; Giranda, Vincent L.
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 7 p. 2000 - 2007
